脑梗死患者血清hs-CRP、LDL-C、IL-6、UA水平与动脉粥样硬化程度的相关性分析

Correlation analysis of serum levels of hs-CRP,LDL-C,IL-6,UA and atherosclerosis in patients with cerebral infarction

目的探究脑梗死患者血清hs-CRP、LDL-C、IL-6、UA水平与动脉粥样硬化程度的相关性。方法选择我院2021年7月~2022年12月收治的92例脑梗死患者为A组,同期健康体检者92例为B组,均进行颈动脉超声检查。按照斑块粥样硬化程度将A组分为无斑块组(n=34)、稳定斑块组(n=28)、易损斑块组(n=30),均进行血清hs-CRP、UA、LDL-C、IL-6水平检测。比较A组与B组以及A组内各亚组患者的各项指标变化,分析各指标与脑梗死动脉粥样硬化程度的相关性。结果血清hs-CRP、UA、IL-6及LDL-C水平:A组>B组(P<0.05),无斑块组<稳定斑块组<易损斑块组(P<0.05);Spearman相关分析结果显示动脉粥样硬化程度与hs-CRP、UA、IL-6及LDL-C水平呈正相关(P<0.05)。结论脑梗死患者血清hs-CRP、UA、IL-6及LDL-C水平异常,尤其是稳定斑块组和易损斑块组更为明显,且各指标水平变化与动脉粥样硬化程度呈正相关。

Objective To explore the correlation between the serum levels of hs-CRP,LDL-C,IL-6,UA and the degree of athero-sclerosis in patients with cerebral infarction.Methods Ninety-two patients with cerebral infarction admitted to our hospital from July 2021 to December 2022 were selected as group A,and 92 healthy people in the same period were selected as group B.Carotid artery ultrasound was performed in all patients.Group A was divided into non plaque group(n=34),stable plaque group(n=28),and vulnerable plaque group(n=30)according to the degree of plaque atherosclerosis.Serum hs-CRP,UA,LDL-C,and IL-6 levels were detected and compared between group A and group B.The changes of serum hs-CRP,UA,LDL-C,IL-6 levels in patients with different degrees of atherosclerosis in group A,and the correlation between each index and the degree of atherosclerosis in cerebral infarction was analyzed.Results The serum levels of hs-CRP,UA,IL-6,and LDL-C in Group A were higher than those in Group B(P<0.05);The serum levels of hs-CRP,UA,IL-6,and LDL-C were:non plaque group<stable plaque group<vulnerable plaque group(P<0.05);Spearman correlation analysis showed that the degree of ath-erosclerosis was positively correlated with the levels of hs-CRP,UA,IL-6 and LDL-C(P<0.05).Conclusion The levels of hs-CRP,UA,IL-6 and LDL-C in serum of patients with cerebral infarction are abnormal,especially in stable plaque group and vulnerable plaque group.