蝎毒抗菌肽在病原微生物感染中的作用

The role of scorpion venom antimicrobial peptides in pathogenic microorganism infections

抗微生物肽(antimicrobial peptides,AMPs)又称抗菌肽,是一类在自然界生物体中广泛存在且具有多种生物活性的小分子多肽。作为生物体固有免疫系统的关键组成部分,抗菌肽具有广谱抗病毒、抗细菌和抗真菌等生物活性,其抗菌机制独特且不易导致病原微生物产生耐药性,可将代替传统抗生素用于病原性疾病的防治。近年来,越来越多的研究表明,蝎毒抗菌肽在病原微生物感染中起着重要作用。因此,本文就蝎毒抗菌肽在病毒、细菌、真菌等病原微生物感染和相关疾病发生发展中的作用机制进行总结,为研发新型、高效且安全的广谱抗微生物药物提供理论依据和思路。

Antimicrobial peptides(AMPs),also known as antibacterial peptides,are a class of small molecular peptides with various biological activities,and are widely existed in living organisms in nature.AMPs typically have a broad-spectrum antibacterial activity against pathogenic microorganisms such as viruses,bacteria and fungi serve as a key components of the innate immune system of organisms.In addition,AMPs can be used as an alternative to traditional antibiotics for treating pathogenic microorganism infections,due to their unique antibacterial mechanisms and low potential to elicit resistance.In recent years,increasing evidence has shown that scorpion venom-derived AMPs plays an important role in pathogenic microorganism infections.Therefore,this article summarizes the mechanisms of action of scorpion venom-derived AMPs in the development of viral,bacterial,fungal and other pathogens infection and related diseases,and provides a theoretical basis and insights for the research and development of new,efficient,broad-spectrum antimicrobial drugs.