髓系肉瘤的诊疗进展

Progress of diagnosis and treatment of myeloid sarcoma

髓系肉瘤(MS)是由髓系原始或未成熟细胞在髓外浸润形成的实体肿瘤。病理检查是诊断的金标准, 但误诊率高, 免疫组织化学染色可减少误诊, 分子生物学及细胞遗传学是重要的辅助诊断指标。影像学技术, 尤其是氟代脱氧葡萄糖标记的正电子发射断层扫描(FDG PET-CT)对MS诊断有重要意义。急性髓系白血病(AML)化疗方案联合造血干细胞移植是当前MS的主要治疗方法。

Myeloid sarcoma(MS)is a solid tumor formed by extramedullary infiltration of primitive or immature cells of the myeloid lineage.Pathology is the gold standard for diagnosis,but the misdiagnosis rate is high.Immunohistochemical staining can reduce misdiagnosis.Molecular biology and cytogenetics are important complementary diagnostic indicators.Imaging techniques,especially fluorodeoxyglucose positron emission tomography-computed tomography(FDG PET-CT),are important for the diagnosis of MS.Acute myeloid leukemia(AML)chemotherapy regimen combined with hematopoietic stem cell transplantation is currently the main treatment for Ms.