儿童炎症性肠病血液生物标志物研究进展

Progress on blood biomarkers for inflammatory bowel disease in children

炎症性肠病是消化系统疾病中较常见的难治性慢性疾病,患病率呈现逐年增加的趋势。炎症性肠病患者的延迟诊断普遍存在,影响患者的病程和结局。早期识别、早期诊断能够明显改善炎症性肠病患者的预后。由于内镜检测的创伤性,寻找可靠的无创性检测标志物十分重要。该文旨在介绍近年来儿科领域具有早期诊断价值的血液生物标志物的研究进展,总结了几种用于鉴别炎症性肠病与非炎症性肠病、溃疡性结肠炎与克罗恩病的新型标志物,并讨论了儿童与成人炎症性肠病标志物的不同之处,并对未来研究方向提出建议,以期帮助临床医生尽早准确识别炎症性肠病,改善患者预后。

Inflammatory bowel disease is a common and refractory chronic disease in digestive system diseases,and its prevalence is increasing year by year.Delayed diagnosis is prevalent in patients with inflammatory bowel disease,affecting the course and outcome of the patient's illness.Early identification and early diagnosis can significantly improve the prognosis of patients with inflammatory bowel disease.Because of the traumatic nature of endoscopic testing,it is important to find reliable non-invasive test markers.This paper aims to introduce the recent progress of blood biomarkers with early diagnostic value in pediatrics,and summarize several novel markers for distinguishing inflammatory bowel disease from non-inflammatory bowel disease,ulcerative colitis and Crohn's disease,as well as discussing the differences of inflammatory bowel disease between children and adults,and providing suggestions for future research to help clinicians identify inflammatory bowel disease accurately as soon as possible and improve patient prognosis.