竞争性内源RNA网络对肝细胞癌微环境调控作用的研究进展

Research progress of competing endogenous RNA network in regulation of hepatocellular carcinoma microenvironment

肿瘤微环境(tumor microenvironment,TME)是不同细胞类型相互作用的产物,在肿瘤的发生发展中起至关重要的作用,因此成为调控肝细胞癌(hepatocellular carcinoma,HCC)发生、发展、侵袭和转移必不可少的内在部分。竞争性内源RNA(competing endogenous RNA,ceRNA)作为肿瘤-宿主相互作用的重要组成部分,能够通过调节不同种类RNA之间的相互作用参与免疫细胞的浸润、分化等功能。但在HCC中,ceRNA网络与TME之间的调节机制是复杂和不确定的。本文对TME中基于ceRNA网络如何促进HCC的发生作一综述,包括肿瘤的侵袭和转移、血管生成、免疫调节及纤维化,以明确ceRNA在HCC发生发展中的特定作用。

Tumor microenvironment(TME)is the product of the interaction of different cell types,which plays a crucial role in the occurrence and development of tumors.Therefore,it is an essential intrinsic part in the regulation of the occurrence,development,invasion and metastasis of hepatocellular carcinoma(HCC).Competing endogenous RNAs(ceRNAs),as an emerging component of tumor-host interaction,can participate in the infiltration and differentiation of immune cells by regulating the interactions between different types of RNAs.However,the regulatory mechanism between ceRNA network and TME in HCC is complex and uncertain.In this review,we focus on how the ceRNA network in TME promotes HCC,including tumor invasion and metastasis,angiogenesis,immune regulation and fibrosis,so as to clarify the specific role of ceRNA in the development of HCC.