肠道微生物介导免疫系统影响骨代谢

Gut microbiota mediating the immune system to affect bone metabolism

近期研究发现,肠道微生物(gut microbiota,GM)可通过调控宿主代谢水平、内分泌及免疫系统等途径影响骨质疏松症(osteoporosis,OP)。其中,GM及其代谢产物通过影响免疫细胞发育分化或介导免疫过程相关信号通路调控骨代谢是重要一环。本文总结GM通过影响宿主免疫系统在OP进程中发挥作用的途径,以期为未来预防或治疗OP提供新思路。

Gut microbiota(GM)plays a key role in regulating various physiological and pathological processes related to human health.Recent studies have found that GM can affect osteoporosis(OP)by regulating the host metabolic level,endocrine and immune systems.Among them,GM and its metabolites play an important role in regulating bone metabolism by influencing immune cell development and differentiation or mediating immune process-related signaling pathways.This article summarized the ways GM acting in the process of OP by influencing the host immune system,in order to provide new ideas for the prevention or treatment of OP in the future.