丹参酮ⅡA磺酸钠联合常规西药治疗不稳定型心绞痛患者的效果

Effect of Sodium TanshinoneⅡA Sulfonate Combined with Conventional Western Medicine in the Treatment of Patients with Unstable Angina Pectoris

目的:分析丹参酮ⅡA磺酸钠联合常规西药治疗不稳定型心绞痛(UAP)的临床效果。方法:回顾性收集2021年3月—2023年3月本院收治的118例UAP患者资料,随机分为对照组和观察组,各59例。对照组采用常规西药治疗,观察组在对照组基础上加用丹参酮ⅡA磺酸钠治疗。比较两组临床疗效、心绞痛发作频率、持续时间、心功能指标[左室收缩末期容积指数(LVESVI)、左心室射血分数(LVEF)、心排血量(CO)]、Th细胞因子[白介素(IL-4、IL-10)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)]及MACE发生情况。结果:治疗后,观察组临床总有效率为91.53%,高于对照组的77.97%(P<0.05);观察组心绞痛发作频率、持续时间低于对照组(P<0.05);观察组LVEF、CO、IL-4、IL-10高于对照组,LVESVI、TNF-α、IFN-γ低于对照组(P<0.05);观察组MACE发生率为5.08%,低于对照组的16.95%(P<0.05)。结论:丹参酮ⅡA磺酸钠治疗UAP疗效显著,有助于减轻患者症状,调控Th1/Th2免疫平衡,增强心功能。

Objective:To analyze the clinical effect of sodium tanshinoneⅡA sulfonate combined with conventional western medicine in the treatment of unstable angina pectoris(UAP).Methods:The data of 118 patients with UAP admitted to our hospital from March 2021to March 2023 were retrospectively collected and randomly divided into a control group and an observation group,with 59 patients in each group.The control group was treated with conventional Western medicine,while the observation group was treated with sodium tanshinoneⅡA sulfonate on the basis of the control group.The clinical efficacy,frequency and duration of angina attacks,cardiac function indicators[left ventricular end-systolic volume index(LVESVI),left ventricular ejection fraction(LVEF),cardiac output(CO)],Th cytokines[interleukin(IL-4,IL-10),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)],and the occurrence of MACE were compared between the two groups.Results:After treatment,the total clinical effective rate in the observation group was 91.53%,which was higher than 77.97%in the control group(P<0.05).The frequency and duration of angina attacks in the observation group were lower than those in the control group(P<0.05).The LVEF,CO,IL-4,and IL-10 levels in the observation group were higher than those in the control group,while the LVESVI,TNF-α,and IFN-γlevels were lower than those in the control group(P<0.05).The incidence of MACE in the observation group was 5.08%,which was lower than 16.95%in the control group(P<0.05).Conclusion:Sodium tanshinoneⅡA sulfonate is effective in the treatment of UAP,which is helpful to alleviate the symptoms of patients,regulate the immune balance of Th1/Th2,and enhance cardiac function.