慢性萎缩性胃炎患者长期使用质子泵抑制剂与癌前病变风险的研究

Study on Long-term use of Proton Pump Inhibitors and Risk of Precancerous Lesions in Patients with Chronic Atrophic Gastritis

慢性萎缩性胃炎是一种炎症性疾病,其特征为胃黏膜干细胞逐渐减少。质子泵抑制剂(PPIs)是减少胃酸分泌最有效的药物。近年来有研究表明,长期使用PPIs可能会增加患者罹患癌前病变的风险。癌前病变是指恶性肿瘤发展前的早期阶段,包括不典型增生、异型增生和原位癌等。尽管这一问题已被广泛研究,但结果不一致。因此,本文对慢性萎缩性胃炎患者长期使用PPIs与癌前病变风险之间的关系进行综述,以期为临床治疗提供参考。

Chronic atrophic gastritis is an inflammatory disease characterized by a progressive decrease of gastric mucosa stem cells.Proton pump inhibitors are the most effective drugs for reducing gastric acid secretion.In recent years,it has been shown that long-term use of PPIs may increase the risk of developing precancerous lesions.Premalignant lesions refer to the early stages before the development of malignancy,including dysplasia,dysplasia,and carcinoma in situ.Although this issue has been extensively studied,the results are inconsistent.Therefore,this article reviews the relationship between the long-term use of PPIs and the risk of precancerous lesions in patients with chronic atrophic gastritis,in order to provide references for clinical treatment.