益气活血散治疗阿尔兹海默病MCI期的认知、日常生活能力、HDS-R评分研究

Yiqi Huoxue San for the treatment of MCI stage of Alzheimer's disease Research on cognition,daily living ability,and HDS-R score

目的用益气活血散治疗阿尔兹海默病MCI期患者认知、日常生活能力、HDS-R校价研究。方法选取2023年8月-2024年8月收治的98例阿尔兹海默病MCI期患者作为受试人员,随机分为观察组和对照组各49例,对照组患者,采用阿米三嗪萝巴新片治疗,观察组患者服用益气活血散加阿米三嗪萝巴新片治疗。以4周为1疗程,连续3个疗程。观察2组患者治疗前后认知、日常生活能力、HDS-R评分变化与临床疗效。结果观察组总有效率96.8%,对照组总有效率76.5%,总有效率比对照组高,有明显差异,具有统计学意义(P<0.05),观察组日常能力评分为(7.64±2.12)分,HDS—R评分为(23.45±4.68)分,日常生活能力评分为(25.66±2.63)分,对照组认知评分为(3.77±2.45)分,HDS—R评分为(16.84±3.92)分,日常生活能力评分为(33.68±2.91)分,观察组两组MCI患者治疗后对比认知、日常生活能力、HDS-R值均明显增高,差异有统计学意义(P<0.05)。结论用益气活血散治疗MCI期显著疗效,明显改善患者的认知、日常生活能力、HDS-R的功能。

Objective:To study the cognitive,daily living ability,and HDS-R cost-effectiveness of patients with MCI stage of Alzheimer's disease treated with Yiqi Huoxue San.Method:98 patients with MCI stage Alzheimer's disease admitted from August 2023 to August 2024 were selected as subjects and randomly divided into an observation group and a control group,with 49 patients in each group.Patients in the control group were treated with Amitriptyline Loquat New Tablets,while patients in the observation group were treated with Yiqi Huoxue Powder combined with Amitriptyline Loquat New Tablets.Take 4 weeks as one course of treatment,with 3 consecutive courses.Observe the changes in cognition,daily living ability,HDS-R score,and clinical efficacy of two groups of patients before and after treatment.The total effective rate of the observation group was 96.8%,while that of the control group was 76.5%.The total effective rate was significantly higher than that of the control group,with statistical significance(P<0.05).The daily ability score of the observation group was(7.64±2.12)points,the HDS-R score was(23.45±4.68)points,and the daily living ability score was(25.66±2.63)points.The cognitive score of the control group was(3.77±2.45)points,the HDS-R score was(16.84±3.92)points,and the daily living ability score was(33.68±2.91)points.After treatment,the cognitive,daily living ability,and HDS-R values of the two groups of MCI patients in the observation group were significantly increased,and the differences were significant.Statistical significance(P<0.05).Conclusion:The use of Yiqi Huoxue San has a significant therapeutic effect on MCI,significantly improving patients'cognition,daily living ability,and HDS-R function.