生物钟节律与机体睡眠及免疫力交互作用的研究进展

Advances in the Study of Circadian Rhythms Interacting with Sleep and Immunity

随着经济社会的发展,为了适应生活和工作的需要从事夜班/倒班工作的人越来越多,继发的睡眠障碍及免疫力低下成为一种普遍现象,严重影响人类健康。基于这一普遍现象,很多研究报告提示生物钟节律与机体睡眠及免疫力之间具有交互作用。本文综述了不同原因造成的生物钟节律异常对个体睡眠的影响及其分子机制;生物钟节律调控免疫的途径及分子机制;睡眠及免疫相关因素对生物钟节律的影响;睡眠与免疫力之间的相互作用;此外,结合本课题组前期研究,对人乳头瘤病毒(human papilloma virus,HPV)清除中生物钟节律的作用进行了简要阐述,旨在为睡眠、免疫相关疾病的防治,夜班/倒班女性的职业保护提供理论依据,为临床相关疾病的治疗提供可能的生物钟时间干预新思路。

With the development of economy and society,more and more people are engaged in night shift jobs,and secondary sleep disorders and weakened immunity are becoming common in those people,seriously affecting their health.Many reports indicated that the biological rhythms have an interaction with sleep and immunity.Herein,the effects of circadian rhythm abnormalities caused by various reasons on individual sleep and their molecular mechanisms,pathways and molecular mechanisms of immunity regulation with the biological clock,effects of sleep-and immune-related factors on circadian rhythms,and the interaction between sleep and immunity were reviewed.In addition,combined with previous research findings,the role of biological rhythms in human papilloma virus(HPV)clearance was briefly described.The review aims to provide a theoretical basis for the prevention and treatment of sleep-and immune-related diseases,occupational protection for female shift workers,and new ideas for biological clock interventions in the treatment of clinically relevant diseases.