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肿瘤免疫微环境在免疫治疗中的作用

Role of the tumor immune microenvironment in immunotherapy
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摘要 恶性肿瘤严重威胁人类生命健康,是导致死亡的主要原因之一。目前,恶性肿瘤的治疗仍存在化学治疗耐药和免疫逃逸等问题。在肿瘤的发生和发展过程中,肿瘤微环境成为了研究的热点。其中,肿瘤免疫微环境(tumor immune microenvironment,TIME)尤为重要。TIME中的各种细胞类型和信号通路可以显著影响肿瘤细胞的生长、扩散和转移,并决定肿瘤对治疗的敏感性。免疫治疗作为一种新兴的治疗方式,已经成为肿瘤治疗的重要研究方向。基于对TIME的深入研究,免疫治疗开辟了新的治疗途径,具有改变传统治疗方式的潜力。目前主流的免疫治疗方法主要是靶标T细胞,而靶标其他免疫细胞的治疗方法仍在探索中。鉴于TIME的复杂性,研究者将TIME分为不同类型,而不同类型的TIME对不同免疫治疗的反应或存在差异,因此分析TIME与免疫治疗的相关性具有重要意义。 Malignant tumors pose a significant threat to human health and are one of the leading causes of death.Despite advances,cancer treatment still faces challenges such as chemotherapy resistance and immune evasion.During the initiation and progression of tumors,the tumor microenvironment has become a focus of research,with the tumor immune microenvironment(TIME)being particularly crucial.Various cell types and signaling pathways within the TIME can significantly influence tumor growth,spread,and metastasis,and they play a key role in determining tumor sensitivity to treatment.Immunotherapy,an emerging therapeutic approach,has become an important avenue in cancer treatment.Insights gained from studying the TIME have opened new therapeutic pathways in immunotherapy,holding the potential to transform traditional treatment methods.Current mainstream immunotherapies primarily target T cells,while treatments targeting other immune cells are still under exploration.Given the complexity of TIME,researchers categorize TIME into different types,as each type may respond differently to specific immunotherapies.Therefore,analyzing the correlation between TIME and immunotherapy is of considerable importance.
作者 向铃燕 饶洁 袁静萍 阎红琳 XIANG Lingyan;RAO Jie;YUAN Jingping;YAN Honglin(Department of Pathology,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处 《临床与病理杂志》 CAS 2024年第7期991-1000,共10页 Journal of Clinical and Pathological Research
基金 湖北省自然科学基金(2121CFB383)。
关键词 肿瘤免疫微环境 免疫治疗 免疫检查点 嵌合抗原受体T细胞 tumor immune microenvironment immunotherapy immune checkpoints chimeric antigen receptor T cells
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