针灸联合西药治疗失眠阳虚证的疗效观察

Therapeutic efficacy of acupuncture and moxibustion combined with western medicine in the treatment of insomnia with Yang deficiency pattern

目的观察扶阳针灸联合佐匹克隆治疗失眠阳虚证的临床疗效及对情绪、生活质量的影响。方法选取96例失眠患者,按随机数字表法分为观察组与对照组,每组48例。对照组予口服佐匹克隆,观察组在对照组基础上予扶阳针灸治疗。比较两组临床疗效、不良反应及治疗前后的中医证候积分、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分、失眠严重指数(insomnia severity index,ISI)评分、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分、生活质量综合评定问卷(generic quality of life inventory-74,GQOLI-74)评分的变化。结果观察组总有效率高于对照组(P<0.05)。两组治疗后中医证候积分均降低(P<0.05),且观察组低于对照组(P<0.05)。两组治疗后HAMA、HAMD评分降低(P<0.05),且观察组低于对照组(P<0.05)。两组治疗后ISI、PSQI评分降低(P<0.05),GQOLI-74评分升高(P<0.05);且观察组ISI、PSQI评分低于对照组(P<0.05),GQOLI-74高于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论扶阳针灸联合佐匹克隆可改善失眠阳虚证患者的失眠症状、情绪及生活质量,治疗效果好,安全性高。

Objective To observe the clinical efficacy of Fuyang acupuncture and moxibustion combined with zopiclone in the treatment of insomnia with Yang deficiency pattern and the effects on mood and quality of life.Method A total of 96 insomnia patients were selected and divided into the observation group and the control group according to random number table method,with 48 cases in each group.The control group was treated with oral Zopiclone,and the observation group was treated with Fuyang acupuncture and moxibustion in addition.The clinical efficacy and adverse reactions were compared between the two groups.The change of Chinese medicine syndrome scores,Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD),insomnia severity index(ISI),Pittsburgh sleep quality index(PSQI),and generic quality of life inventory-74(GQOLI-74)before and after treatment were compared between the two groups.Result The total effective rate of the observation group was higher than that of the control group(P<0.05).The Chinese medicine syndrome scores of both groups decreased after treatment(P<0.05),and that of the observation group was lower than that of the control group(P<0.05).The HAMA and HAMD scores decreased in both groups after treatment(P<0.05),and those in the observation group were lower than those in the control group(P<0.05).The ISI and PSQI scores decreased(P<0.05)and GQOLI-74 scores increased(P<0.05)after treatment in both groups;and ISI and PSQI scores were lower in the control group than in the observation group(P<0.05),and GQOLI-74 was higher in the observation group than in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Fuyang acupuncture and moxibustion combined with zopiclone can improve insomnia symptoms,mood and quality of life of patients with insomnia of Yang deficiency pattern,with good therapeutic effect and high safety.