肝移植受者术前衰弱对不良健康结局影响的系统评价

A systematic review of the impact of preoperative frailty on adverse health outcomes in liver transplant recipients

目的系统评价术前衰弱对肝移植受者不良健康结局的影响。方法计算机检索中英文数据库,收集有关术前衰弱与肝移植受者不良健康结局的横断面研究、队列研究或病例对照研究,检索时限为建库至2024年1月。由2名研究者独立筛选文献和提取资料,并进行文献质量评价。采用描述性分析法对结果进行整合与分析。结果共纳入14项研究,包括12项队列研究,2项横断面研究,共纳入研究对象6012例。描述性分析结果显示:肝移植受者术前衰弱可导致死亡风险升高,住院时间延长,术后并发症增加,生活质量下降。结论肝移植受者术前衰弱与多种不良健康结局密切相关,医护人员需及早采取干预措施,预防或延缓衰弱发生,改善肝移植受者的健康结局。

Objective To systematically evaluate the impact of preoperative frailty on adverse health outcomes in liver transplant recipients.Methods Chinese and English databases were searched,in order to collect cross-sectional studies,cohort studies,or case-control studies on preoperative debility and adverse health outcomes in liver transplant recipients,the search period was form the establishment of the database up to January 2024.Two researchers independently screened the literatures,extracted the data,and assessed the quality of studies.Descriptive analysis was used to integrate and analyze the results.Results A total of 14 studies were included,including 12 cohort studies and 2 cross-sectional studies,with a total of 6,012 study participants.The results of the descriptive analysis showed that preoperative frailty in liver transplant recipients can lead to an increased risk of death,prolonged hospitalization,increased postoperative complications,and decreased quality of life.Conclusion The preoperative frailty in liver transplant recipients is closely associated with multiple adverse health outcomes.Medical staff should pay more attention to the preoperative frailty in liver transplant recipients and take early interventions in order to prevent or delay the occurrence of frailty and improve the health outcomes of liver transplant recipients.