摘要
2型糖尿病(T2DM)是一种以高血糖和胰岛素抵抗(IR)为特征的代谢性疾病。T2DM患者普遍存在肠道菌群失调,其与疾病的发生以及IR的形成密切相关。本文对肠道菌群参与T2DM相关代谢、炎症反应和免疫紊乱之间的复杂作用关系进行综述,重点分析肠道微生物代谢产物在影响T2DM胰岛素信号传导中的机制。另外,简要探讨了益生菌通过调节肠道菌群及其代谢产物干预T2DM的作用,为基于肠道菌群调控治疗T2DM及其并发症提供理论依据与参考。
Type 2 diabetes mellitus(T2DM)is a metabolic disorder characterized by persistent hyperglycemia and insulin resistance(IR).Emerging evidence indicates that gut microbiota dysbiosis is closely linked to the onset of T2DM and the progression of IR.This review provides a comprehensive analysis of the intricate interactions between gut microbiota and the metabolic,inflammatory,and immune dysregulation observed in T2DM.It specifically emphasizes the mechanisms through which microbial metabolites modulate insulin signaling pathways in the context of T2DM.Additionally,the review explores the potential of probiotics as a therapeutic intervention,focusing on their ability to modulate gut microbiota and its metabolites.This review offers a theoretical framework and relevant literature to support the regulation and treatment of T2DM and its complications via gut microbiota modulation.
作者
邓小玲
石立力
Deng Xiaoling;Shi Lili(Department of Cadre Ward,the First Affiliated Hospital of Harbin Medical University,Harbin 150081)
出处
《国际老年医学杂志》
2024年第6期641-647,共7页
International Journal of Geriatrics
基金
黑龙江省自然联合引导项目(LH2022H038)。
关键词
2型糖尿病
肠道菌群
益生菌
胰岛素抵抗
Type 2 diabetes mellitus
Gut microbiota
Probiotics
Insulin resistance
