脂质成分与代谢在帕金森病发生中的研究进展

Insights into Lipid Metabolism and Composition in Parkinson's Disease Pathogenesis

帕金森病(PD)是一种神经系统慢性退行性疾病,其患病人数逐年增多,脂质既具有结构功能又具有生理作用,在大脑结构的发育过程以及维持神经细胞的正常生理活动中发挥着至关重要的作用。脂质代谢参与了PD的病理进展。综述主要总结了PD中的脂代谢异常及其造成的病理损伤,以及基于脂类代谢的治疗、相关药物研究方向的进展和未来的前景。

Parkinson's disease(PD)is a chronic degenerative disorder of the nervous system.Lipids,as fundamental components of cells,are integral to both structural functions and physiological roles.They are essential for the development of brain structures and the maintenance of normal physiological activity in nerve cells.Lipid metabolism is intricately involved in the pathological progression of PD.This review primarily summarizes the abnormalities in lipid metabolism observed in PD,the resultant pathological damage,and lipid metabolism-based therapeutic strategies.Additionally,it discusses recent advancements in related drug research and explores future prospects in this field.