细胞焦亡在口腔感染性疾病中的研究进展

The Role of Pyroptosis in Oral Infectious Diseases: Current Research Progress

口腔微生物失调是口腔感染性疾病的初始因素,但牙周组织的破坏程度由微生物与宿主免疫反应之间的相互作用决定。细胞焦亡作为重要的天然免疫反应,在口腔感染性疾病的发生发展中发挥重要作用。本文对细胞焦亡的分子机制,不同口腔微生物引起焦亡的通路及组织破坏的病理生理机制作一综述,为防治口腔感染性疾病提供新思路。

In oral infectious diseases,the imbalance of oral microorganisms is considered a primary factor,however,the extent of periodontal tissue destruction is determined by the interaction between microbiota and the host immune response.Pyroptosis,a crucial innate immune response,plays a significant role in the onset and progression of oral infectious diseases.This paper reviews the molecular mechanisms of pyroptosis,the pyroptosis pathways triggered by various oral microorganisms,and the pathophysiological mechanisms of tissue destruction.The aim is to offer novel insights for the prevention and treatment of oral infectious diseases.