基于文献计量学及专利分析的中药药理学学科进展——以中国中医科学院中药研究所为例

TCM Pharmacology Based on Bibliometrics and Patent Analysis:A Case Study of Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences

目的:分析中国中医科学院中药研究所(以下简称“中药所”)中药药理学学科相关文献,评估其研究现状、发展趋势、学科成员学术影响力,以及专利技术情况。方法:检索中国知网(CNKI)、Web of Science(WOS)数据库中2002—2024年以第一作者或通讯(信)作者,且作者单位为中药所的学科成员论文,使用CiteSpace 6.3.R6对年发文量、关键词进行可视化分析;对中药所中药药理学学科成员的论文发文总数、被引次数等测度参数进行统计,得出h指数后计算学术迹,从学术迹T、高被引论文等方面对学科成员学术影响力量化测评;从HimmPat专利数据库检索中药所中药药理学学科2005—2024年的专利数据,采用Excel 2022及Origin 2021对专利整体申请趋势、技术构成等进行可视化分析。结果:在过去20余年,学科论文年发表量整体呈上升趋势,关键词热点包含“动物模型”“作用机制”“网络药理学”等;研究热点聚焦在中药药理机制创新方法、中药防治重大非感染性疾病和中药防治呼吸道病毒性疾病的基础研究等。中药所中药药理学学科成员学术迹T均为正值,个人影响力良好。近几年专利申请趋势增长明显,主要集中在A61K类专利、G01N小类,IPC大组分析显示主要技术应用集中在A61K36、A61K31等领域。结论:中药所中药药理学学科发展稳步向上,学科成员学术影响力尚可,专利成果丰富。未来可继续加强药理学科创新研究和新药研发,开展多学科交融研究,促进中药现代化。

Objective:To analyze the literature related to traditional Chinese medicine(TCM)pharmacology of Institute of Chinese Materia and Medica,China Academy of Chinese Medical Sciences(hereinafter referred to as"Institute of Chinese Materia and Medica"),and evaluate the research status,development trend,influence of discipline members,and patent technology of this field.Method:The papers from 2002 to 2024 in the databases of CNKI and Web of Science(WOS)were searched,whose first authors or corresponding authors are from the Institute of Chinese Materia and Medica,and CiteSpace 6.3.R6 was adopted for visual analysis of the annual number of publications and keywords.Additionally,the total number of published papers,citation times,and other measurement parameters of discipline members of TCM pharmacology in the institute were counted.After obtaining the h index,the academic track was calculated,and the academic influence of discipline members was quantitatively evaluated from the aspects of the academic track T and highly cited papers.Meanwhile,patent data from 2005 to 2024 of TCM pharmacology in the studied institute were retrieved from the HimmPat patent database,and Excel 2022 and Origin 2021 were utilized to conduct visual analysis on the overall patent application trend and technology composition.Result:In the past 20 years or more,the annual publication of academic papers has been on the rise generally,and the key words include"animal model","mechanism of action","network pharmacology"and so on.The studies focus on the innovative methods of TCM pharmacological mechanisms,basic research on TCM prevention and treatment of major non-infectious diseases,and the prevention and treatment of respiratory viral diseases.The academic track T of the discipline members of TCM pharmacology in the Institute of Chinese Materia and Medica is positive,with sound personal influence.In recent years,the patent application trend has increased significantly,mainly concentrating on A61K patents and G01N subcategories,and IPC large-group analysis shows that the main technical applications are mainly in A61K36,A61K31,and other fields.Conclusion:TCM pharmacology in the institute develops steadily and the academic influence of the discipline members is still sound,with fruitful patent achievements.In the future,research on pharmacological discipline innovation and new drug research and development can be enhanced,and multidisciplinary integration studies should be carried out to promote TCM modernization.