中药复方配伍科学内涵阐释研究的理论概述

A Review of Theoretical Research on Interpretation of Scientific Connotation of Compatibility of Traditional Chinese Medicine Compounds

中医药学在中国有悠久应用历史,并且历来和正在发挥着重要的治病救人作用,中药复方是临床中医主要的施治形式,由于中药复方药味组成和化学成分繁多显著区别于化学药,中药复方有着临床治疗效应差异大、复杂难以合理掌控等障碍,但是,中药复方潜在的多成分、多靶点、多途径作用特点也显现其区别于单一成分化学药的互补治疗优势,所以,随着现代科技的发展和中医药现代化、国际化的需求驱动,有关中药复方效应复杂性研究的现代化理论被不断提出:复方是中医整体观治疗作用的主要体现,区别于传统复方理论的抽象化语言,现代化的中药复方理论更倾向于从实验和科学的角度具体形象地阐明复方配伍内涵。该文梳理归纳近年来提出的复方复杂性研究新理论,以期为中药复方发挥更大作用和得到更好的科学认识提供研究参考和思路。

Traditional Chinese medicine(TCM)has a long history of application in China and has consistently played a vital role in treating diseases and saving lives.TCM prescriptions(compounds)constitute the primary form of clinical TCM treatment and significantly differ from western medicine(chemicals)due to the diverse composition and chemical constituents of TCM(compounds).Nevertheless,the potential multicomponent,multi-target,and multi-pathway action characteristics of TCM prescriptions also demonstrate their possible(complementary)therapeutic advantages when compared with single-component chemical drugs.Therefore,driven by the development of modern science and technology and the demands of the modernization and internationalization of TCM,modern theories regarding the complexity of TCM prescription effects have been continuously proposed:Different from the abstract language of traditional prescription theory,the modern TCM prescription theory is more inclined to illustrate the connotation of prescription compatibility concretely and vividly from an experimental and scientific perspective.In this paper,new theories on the complexity of TCM prescriptions proposed in recent years are summarized to provide research references and ideas for the greater role of TCM prescriptions and a better scientific understanding.