摘要
对黄皮树(Phellodendron chinense)干燥树皮的非生物碱部分进行化学成分研究。采用硅胶柱色谱、中压液相色谱、葡聚糖凝胶Sephadex LH-20柱色谱及制备液相色谱等多种色谱技术,从黄皮树95%乙醇提取物中分离鉴定了14个化合物,其中isophellolactone(1)为新化合物。对这14个化合物进行了抑制α-葡萄糖苷酶活性筛选,首次发现奎宁酸酯类化合物3~6和8有较好的抑制α-葡萄糖苷酶活性,多羟基六元碳环可能是其活性的关键基团。
The non-alkaloid chemical constituents of dried Phellodendron chinense barks were investigated.A total of 14 phenolic compounds(1-14)were isolated from the 95%ethanol extract of Phellodendron chinense by the utilization of silica gel,medium pressure liquid chromatography,Sephadex LH-20 column chromatography,and preparative liquid chromatography.Among of the isolated compounds,isophellolactone(1)was identified as a new compound.The isolated 14 compounds were further tested the activity onα-glucosidase inhibition.The results for the first time demonstrated that quininic acid ester 3-6 and 8 exhibited goodα-glucosidase inhibitory activity.Polyhydroxy hexa-membered carbon ring in quinine ester derivatives is possibly the essential group for theα-glucosidase inhibitory activity.
作者
张玉林
李思琪
朱兰珠
陈宣钦
ZHANG Yu-lin;LI Si-qi;ZHU Lan-zhu;CHEN Xuan-qin(Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500,China)
出处
《药学学报》
CAS
CSCD
北大核心
2024年第11期3130-3134,共5页
Acta Pharmaceutica Sinica
基金
云南省重点研发计划-中药防治新发突发传染病产业技术创新平台建设及示范应用(202103AC10005)。
