肌-脑轴在老年人肌少症与认知功能障碍关系中的作用

The role of muscle-brain axis in the relationship between sarcopenia and cognitive impairment in the elderly

衰弱是一种与增龄相关的老年综合征,表现为机体生理储备功能减退后对应激和维持自稳态的能力下降,增加跌倒、失能甚至死亡的风险。认知功能障碍是由多种原因导致的认知功能损害,介于正常衰老和痴呆之间。衰弱的早期尚有一定的可逆性。肌少症是生理衰弱的核心,研究显示肌少症和认知障碍密切相关,肌-脑轴是肌少症与认知障碍之间的纽带。本文对肌-脑轴在肌少症合并认知功能障碍中可能存在的作用机制进行综述,为探寻干预肌少症和认知障碍新靶点提供参考依据。

Frailty is a geriatric syndrome associated with aging,which is characterized by a decrease in the ability to stress and maintain homeostasis after the loss of physiological reserve function,resulting in an increased risk of falls,disability,and even death.Cognitive impairment is a disorder of cognitive function due to a variety of causes,between normal aging and dementia.In the early stages,frailty is a certain reversibility.As the core of physical frailty,sarcopenia has been a research hotspot in recent years.With the deep research on sarcopenia,researchers have found that is closely related to cognitive disorder.Muscle-brain axis may play a role in sarcopenia and cognitive impairment.This article illustrates its possible mechanisms at the crossroad of sarcopenia and cognitive disorder,and to provide reference for exploring new targets for intervention of sarcopenia and cognitive impairment.