超声激励微泡空化在新型辅助治疗中的应用及进展

Application and progress of ultrasound-stimulated microbubble cavitation in novel adjuvant therapies

超声激励微泡空化(USMC)是超声场中震荡微泡引发的空化现象,该效应已在提高细胞膜的通透性、增强肿瘤细胞对化疗或免疫治疗的敏感性及增加溶栓药物对血栓渗透和血管再通方面取得了突破性进展。近年来,超声医学与材料学的交叉融合催生了超声响应性多功能纳米级微泡的研究,提升了USMC治疗效果。本文综述了USMC在改善缺血疾病的组织灌注、肿瘤化疗和免疫治疗、超声溶栓等方面的应用及研究进展。

Ultrasound-stimulated microbubble cavitation(USMC)is a cavitation phenomenon triggered by oscillating microbubbles in ultrasound field,and this effect has led to breakthroughs in improving the permeability of cell membranes,enhancing the sensitivity of tumor cells to chemotherapy or immunotherapy,and increasing the penetration of thrombolytic drugs into blood clots and vascular recanalization.In recent years,the cross-fertilization of ultrasound medicine and materials science have given rise to the study of ultrasound-responsive multifunctional nanobubble to enhance USMC treatment.This article reviews the application and research progress of USMC in improving tissue perfusion in ischemic diseases,tumor chemotherapy and immunotherapy,ultrasonic thrombolysis,and other treatments.