高压氧联合盐酸米诺环素软膏治疗慢性牙周炎的疗效及对血清LF、CCL2水平的影响

Clinical efficacy of hyperbaric oxygen combined with minocycline hydrochloride ointment on chronic periodontitis and its effect on serum LF and CCL2

目的观察高压氧联合盐酸米诺环素软膏治疗慢性牙周炎患者的临床疗效及对血清乳铁蛋白(LF)、趋化因子C-C配体2(CCL2)水平的影响。方法选择2021年5月至2023年5月东营市人民医院口腔科收治的92例慢性牙周炎患者作为研究对象,采用随机数字表法分为观察组(n=46)和对照组(n=46)。对照组患者予以盐酸米诺环素软膏治疗,观察组采取高压氧联合盐酸米诺环素软膏治疗。比较2组患者的临床疗效、牙周健康指标和血清LF、CCL2治疗前后水平的变化,同时记录治疗期间不良反应发生情况。结果治疗4个疗程后,观察组患者治疗总有效率(95.65%)明显高于对照组(80.43%),差异有统计学意义(χ^(2)=4.221,P<0.05)。与治疗前比较,2组患者治疗后牙周袋深度、牙龈指数、牙菌斑指数、龈沟出血指数均明显降低,且治疗后观察组均明显低于对照组(P<0.01)。与治疗前比较,2组患者治疗后血清CCL2、LF水平均明显降低,且治疗后观察组均明显低于对照组(P<0.01)。在治疗过程中,观察组不良反应总发生率(4.35%)与对照组(8.70%)比较差异无统计学意义(χ^(2)=0.713,P=0.398)。结论高压氧联合盐酸米诺环素软膏治疗慢性牙周炎主要是通过降低患者血清CCL2、LF水平,缓解牙周局部炎症反应,以提高临床治疗效果。

Objective To observe the effects of hyperbaric oxygen combined with minocycline hydrochloride ointment on serum lactoferrin(LF)and the chemokine C-C motif ligand 2(CCL2)in elderly patients with chronic periodontitis.Methods A total of 92 elderly patients with chronic periodontitis admitted to Department of Stomatology,People’s Hospital of Dongying from May 2021 to May 2023 were chosen as research subjects and divided into observation group and control group according to the random number table method,with 46 cases in each group.The control group was treated with minocycline hydrochloride ointment,and the observation group was treated with hyperbaric oxygen combined with minocycline hydrochloride ointment.The changes of periodontal health indicators,serum LF,CCL2 levels before and after treatment,as well as the occurrence of adverse reactions during treatment and clinical efficacy were compared between the two groups.Results The total effective rate of the study group(95.65%)was higher than that of the control group(80.43%),with a statistically significant difference(χ^(2)=4.221,P<0.05).After treatment,the periodontal pocket depth,gingival index,dental plaque index,and gingival sulcus bleeding index decreased in both groups,and the decreases were more significant in observation group than those in control group(P<0.01).After treatment,the serum levels of CCL2 and LF decreased in both groups,and the decreases were more obvious in observation group than those in control group(P<0.05).During the treatment,the difference of the total incidence of adverse reactions between the observation group(4.35%)and the control group(8.70%)was not statistically significant(χ^(2)=0.713,P=0.398).Conclusion Hyperbaric oxygen combined with minocycline hydrochloride ointment can effectively relieve the periodontal inflammation in elderly patients and improve clinical efficacy,through reducing serum CCL2 and LF levels.