基于CiteSpace知识图谱对蛋白质脱酰胺研究进展的可视化分析

Visual Analysis of Research Progress on Protein Deamidation Based on CiteSpace Knowledge Map

为了探究蛋白质脱酰胺的研究热点与发展趋势,系统地检索了中国知网(CNKI)和Web of Science(WOS)核心数据库中关于蛋白质脱酰胺的133篇中文文献和337篇英文文献,采用CiteSpace软件对发文量趋势、作者合作网络、国家合作网络、机构合作网络以及关键词等内容绘制知识图谱并进行分析及可视化展示。结果表明:中文发文量较少,呈平稳趋势;英文发文量呈波浪式上升趋势,且2020—2023年发文量增长迅速,每年都在30篇以上。此外,中英文文献的作者之间都形成了相对固定的作者集群,群体内合作联系较为紧密,但集群之间合作联系较少;国内外在该领域的研究热点大体一致,都是以脱酰胺对蛋白质结构及功能特性的影响为主,在其影响功能特性的机理及蛋白质的致敏性方面也开展了部分研究;近年来,蛋白质谷氨酰胺酶在蛋白质脱酰胺领域的应用成为热点。

In order to explore the research hotspots and development trends of protein deamidation,this paper systematically searched 133 Chinese literatures and 337 English literatures on protein deamidation in the CNKI and WOS databases,and the CiteSpace software was used to draw knowledge graphs and visual analysis of publication trends,author collaboration networks,national collaboration networks,institutional cooperation network,keywords and other content.The results showed that the volume of Chinese publications was relatively low and showed a steady trend,while the volume of English publications showed a wave-like upward trend,with a rapid increase from 2020 to 2023,exceeding 30 publications per year.In addition,both Chinese and English literature formed relatively fixed author clusters with close collaborations within the groups,but limited collaborations between clusters.The research hotspots in this field were generally consistent domestically and internationally,mainly focusing on the influence of deamidation on the structure and functional characteristics of proteins.Some research has also been conducted on the mechanisms underlying the influence on functional characteristics and the sensitization of proteins.In recent years,the application of protein glutaminase in the field of protein deamidation has become a new research hotspot.