阿替普酶静脉溶栓治疗轻型缺血性脑卒中患者的效果

Effect of Alteplase Intravenous Thrombolytic Therapy on Patients with Mild Ischemic Stroke

目的:研究阿替普酶静脉溶栓疗法治疗轻型缺血性脑卒中患者的效果。方法:选取2021年1月—2022年12月北京航天总医院神经内科收治的80例轻型缺血性脑卒中患者为研究对象,应用随机抽签法将其分为对照组和试验组,各40例,对照组采用常规对症治疗,试验组在对照组基础上采用阿替普酶溶栓治疗,比较两组治疗效果、不良反应发生情况、神经缺损程度、自理能力、生活质量。结果:试验组的治疗总有效率为97.50%,高于对照组的82.50%,差异有统计学意义(P>0.05)。治疗后,试验组Barthel指数、健康调查简表评分均高于对照组,美国国立卫生研究院卒中量表评分低于对照组,差异均有统计学意义(P<0.05)。试验组不良反应发生率为7.50%,低于对照组的10.00%,但差异无统计学意义(P>0.05)。结论:阿替普酶溶栓疗法治疗轻型缺血性脑卒中患者可取得良好效果,利于恢复患者神经功能,改善生活质量及自理能力,具有良好的应用价值。

Objective:To study the effect of Alteplase intravenous thrombolytic therapy on patients with mild ischemic stroke.Methods:A total of 80 patients with mild ischemic stroke admitted to the Beijing Aerospace General Hospital from January 2021 to December 2022 were selected as the study objects,and were divided into a control group and an experimental group by random drawing method,with 40 cases in each group.The control group received conventional symptomatic treatment,and the experimental group received Alteplase thrombolytic therapy on the basis of the control group.The treatment effect,occurrence of adverse reactions,degree of nerve defect,self-care ability and quality of life were compared between the two groups.Results:The total effective rate of the experimental group was 97.50%,which was higher than 82.50%of the control group,the difference was statistically significant(P>0.05).After treatment,the score of Barthel Index and the MOS Item Short Form Health Survey of the experimental group were higher than those of the control group,and the National Institutes of Health Stroke Scale score was lower than that of the control group,with statistical significance(P<0.05).The incidence of adverse reactions in the experimental group was 7.50%,which was lower than 10.00%in the control group,but the difference was not statistically significant(P>0.05).Conclusion:Alteplase thrombolytic therapy can achieve good results in the treatment of patients with mild ischemic stroke,which is beneficial to restore the neurological function of patients,improve the quality of life and self-care ability,and has good application value.