氟哌噻吨美利曲辛联合高压氧治疗围绝经期失眠症患者的临床效果观察

Clinical Efficacy of Flupentixol and Melitracen Combined with Hyperbaric Oxygen in the Treatment of Patients with Perimenopausal Insomnia

目的:分析氟哌噻吨美利曲辛联合高压氧治疗围绝经期失眠症患者的有效性。方法:选择2022年12月—2024年3月临沂市中心医院收治的80例围绝经期失眠症患者为研究对象,根据随机数字表法将其分为对照组和研究组,每组40例。对照组采用氟哌噻吨美利曲辛治疗,研究组在对照组基础上采用高压氧治疗,对比两组治疗总有效率、性激素指标、睡眠质量、不良反应发生情况。结果:研究组治疗总有效率为97.50%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗结束时,研究组的雌二醇高于对照组,卵泡刺激素、促黄体生成激素均低于对照组,差异均有统计学意义(P<0.05)。治疗结束时及治疗4周后,两组睡眠质量评分均低于治疗前,且研究组低于对照组,治疗4周后,两组睡眠质量评分均高于治疗结束时,但研究组低于对照组,差异均有统计学意义(P<0.05)。研究组不良反应发生率为5.00%,低于对照组的7.50%,但两组对比,差异无统计学意义(P>0.05)。结论:氟哌噻吨美利曲辛联合高压氧治疗围绝经期失眠症患者的效果显著,可以提高睡眠质量,改善性激素指标,具有一定的安全性,应用价值较高。

Objective:To analyze the effectiveness of Flupentixol and Melitracen combined with hyperbaric oxygen in the treatment of patients with perimenopausal insomnia.Methods:A total of 80 patients with perimenopausal insomnia treated in Linyi Central Hospital from December 2022 to March 2024 were selected as the study objects,and were divided into a control group and a study group according to random number table method,with 40 cases in each group.The control group was treated with Flupentixol and Melitracen,and the study group was treated with hyperbaric oxygen on the basis of the control group.The total effective rate,sex hormone indexes,sleep quality and the occurrence of adverse reactions of the two groups were compared.Results:The total effective rate of the study group was 97.50%,which was higher than 80.00%of the control group,the difference was statistically significant(P<0.05).At the end of the treatment,the estradiol of the study group was higher than that of the control group,the follicle-stimulating hormone and luteinizing hormone were lower than those of the control group,the differences were statistically significant(P<0.05).At the end of treatment and 4 weeks after treatment,the slcep quality scores in both groups were lower than before treatment,and the study group was lower than the control group;at 4 weeks after treatment,the slcep quality scores in both groups were higher than the end of treatment,but the study group was lower than the control group,with statistical significance(P<0.05).The incidence of adverse reactions in the study group was 5.00%,which was lower than 7.50%in the control group,but there was no statistical significance between the two groups(P>0.05).Conclusion:Flupentixol and Melitracen combined with hyperbaric oxygen is effective in the treatment of perimenopausal insomnia patients,which can improve sleep quality and sex hormone indexes,and has certain safety and high application value.