痛风性关节炎急性发作及自发性消退的病理机制研究

Pathological mechanism of acute attack and spontaneous resolution of gouty arthritis

痛风性关节炎的患病率逐年上升,其急性发作时严重影响工作及生活,慢性反复发作控制不佳有致畸致残风险。靶向降低血尿酸水平,实现晶体溶解是痛风治疗的关键。虽然痛风性关节炎的治疗指南较为完善,用药选择也比较广泛,但临床收效仍不理想。本综述着重阐述了痛风性关节炎急性发作和自发缓解的临床表现其背后的分子和细胞病理机制,通过对其进行深入了解,从而更加深刻地认识规范化临床用药的必要性,并进一步探讨其潜在的治疗策略。

The prevalence of gouty arthritis is increasing year by year.Acute attacks seriously affect work and life.Poor control of chronic recurrent attacks may lead to teratogenicity and disability.Targeted reduction of serum uric acid levels and crystallolysis is the key to gout treatment.Although its treatment guidelines are relatively complete and drug choices are relatively wide,the clinical effect is still not satisfactory.This review focuses on the molecular and cytopathological mechanisms behind the clinical manifestations of acute attack and spontaneous remission of gouty arthritis,so as to further understand the necessity of standardized clinical medica-tion and explore its potential treatment strategies.