应用新型磁力套扎圈实施痔套扎术的可行性和安全性的初步探讨:基于犬直肠黏膜套扎的实验研究

Preliminary exploration of the feasibility and safety of a novel magnetic ligation ring for hemorrhoid ligation:an experimental study based on canine rectal mucosal ligation procedure

目的初步探讨应用新型磁力套扎圈实施痔套扎术的可行性和安全性。方法实验用犬为6只成年拉布拉多犬,应用一次性使用手动负压肛肠套扎吻合器于其直肠黏膜模拟痔套扎术,套扎圈选用笔者团队参与设计的新型磁力套扎圈和(或)普通套扎圈。根据本实验研究设计,每只犬各套扎8枚套扎圈,对6只犬共套扎29枚新型磁力套扎圈和19枚普通套扎圈;对其中2只犬各套扎8枚新型磁力套扎圈,对其中1只犬仅套扎8枚普通套扎圈,其余3只犬均接受混合种类的套扎圈的套扎操作。记录犬直肠黏膜套扎的总体情况和套扎圈的脱落时间(收集粪便,统计术后1周内套扎圈的脱落情况),比较不同种类的套扎圈所需的脱落时间。结果6只犬均按计划完成直肠黏膜套扎操作,操作过程总体顺利,术后总体情况良好,未观察到犬存在明显异常的活动行为,未观察到其粪便有明显的带血迹象,而且脱落的部分新型磁力套扎圈上有发现黏膜组织。应用混合种类的套扎圈的其中2只犬各有1枚普通套扎圈未找到。29枚新型磁力套扎圈的平均所需脱落时间为(3.3±1.7)d;17枚普通套扎圈的平均脱落所需时间为(4.5±1.4)d,两者比较差异有统计学意义(P<0.05)。仅套扎新型磁力套扎圈的2只犬中,16枚套扎圈的平均脱落所需时间为(3.5±1.7)d;仅套扎普通套扎圈的犬中,8枚套扎圈的平均脱落所需时间为(5.3±1.1)d。结论在本实验研究条件下,与应用普通套扎圈相比,应用新型磁力套扎圈进行直肠黏膜套扎操作在套扎圈脱落所需时间方面有潜在的优势。

Objectives To preliminarily explore the feasibility and safety of using a novel magnetic ligation ring for hemorrhoid ligation.Methods Six adult Labradors were used.A disposable manual vacuum ligator was used to simulate hemorrhoid ligation on the canine rectal mucosa,employing novel magnetic ligation ring designed with the participation of our team and/or ordinary rubber ligation ring.According to the experimental study design,each dog received 8 ligation rings,resulting in a total of 29 novel magnetic ligation rings and 19 ordinary rubber ligation rings being applied across the 6 dogs.Two dogs received 8 novel magnetic ligation rings each,1 dog received 8 ordinary rubber ligation rings,and the remaining 3 dogs underwent ligation with both types.The overall condition of the rectal mucosa ligation and the time until ring detachment were recorded(collecting feces to monitor detachment within 1 week postoperation),comparing the detachment time of different types of ligation ring.Results All 6 dogs successfully completed the planned rectal mucosa ligation procedure,and the operations were generally smooth.Post-operative conditions were good,with no significant abnormal activity observed in the dogs,and no evident blood in their feces.Some of the detached novel magnetic ligation rings were found to contain mucosal tissue.In 2 dogs that underwent ligation with both types of ligation ring,1 ordinary rubber ligation ring was not retrieved from each dog.The average detachment time for the 29 novel magnetic ligation rings was(3.3±1.7)days,compared to(4.5±1.4)days for the 17 ordinary rubber ligation rings,with a statistically significant difference(P<0.05).For the 2 dogs that only received novel magnetic ligation rings,the average detachment time was(3.5±1.7)days for 16 rings;whereas for the dog that only received ordinary rubber ligation rings,the average detachment time was(5.3±1.1)days for 8 rings.Conclusion Under the conditions of this experimental study,novel magnetic ligation ring may offer a potential advantage in terms of detachment time when used for rectal mucosa ligation,compared to the ordinary rubber ligation ring.