胶原蛋白肽的制备、生物活性及应用研究进展

Research Progress on Preparation,Biological Activity and Application of Collagen Peptides

胶原蛋白肽具有良好的生物相容性、生物活性及易被人体吸收利用等优点,在食品、生物医用材料及化妆品领域均得到了广泛研究与开发利用。针对近年来胶原蛋白肽在制备方法、生物活性及其应用方面的研究,本文对相关进展进行了归纳与总结。首先,概述了当前胶原蛋白肽的制备方法和原理,并比较了不同方法的优势与不足;其次,归纳了胶原蛋白肽现已发掘的生物活性,包括抗氧化性、抗菌性、抗冻性、血管紧张素转化酶(ACE)抑制活性及二肽基态酶-Ⅳ(DPP-Ⅳ)抑制活性等;最后,探讨了基于上述生物活性,胶原蛋白肽在食品领域中作为食品添加剂和功能性食品的应用情况,同时也介绍了其在医药、化妆品等领域中的最新应用。

Collagen peptides,renowned for their excellent biocompatibility,bioactivity,and facile absorption by human body,have been extensively developed and utilized in the food,biomedical,and cosmetic industries.This review focuses on recent development in the preparation methods,bioactivities,and applications of collagen peptides.Firstly,an overview of the current preparation methods and principles of collagen peptides is provided,followed by a comparison of the advantages and limitations of different methods.Subsequently,a summary of the bioactivities exhibited by collagen peptides is presented,including the antioxidant activity,antimicrobial activity,antifreeze activity,inhibition of angiotensin-converting enzyme(ACE)and dipeptidyl peptidase-IV(DPP-IV).Finally,the application of collagen peptides in food additives and functional foods,based on the bioactivity has been discussed.Additionally,the latest applications of collagen peptides in the fields of medicine and cosmetics have also been introduced.