新都地区1141例妊娠期妇女HPV病毒感染分型及特点研究

Analysis of HPV virus infection typing and characteristies of 1141 cases in pregnant women in Xindu District

目的分析新都地区妊娠期妇女人乳头瘤病毒(HPV)感染分型及特点,并指导妊娠期HPV感染的防治。方法回顾性分析成都市新都区人民医院2022年1至2023年8月妊娠期妇女的病例资料,通过荧光PCR法检测所有病例的HPV分型,并对分型结果进行统计学分析。结果1141例妊娠期妇女中,HPV感染174例,感染率15.25%,其中高危型感染主要为HPV52、58和53型,低危型为HPV44、81型。单基因型感染123例(10.78%),感染型别以HPV52、58和44为主,多基因型感染51例(4.47%),其中双基因型感染29例(2.54%),三重及以上基因型感染22例(1.93%)。16~25岁、26~35岁和36~44岁感染率分别为5.35%、8.94%、0.96%,差异有统计学意义(P<0.05)。妊娠早期、中期、晚期HPV感染率分别为7.36%、7.71%、0.18%,妊娠早期、中期感染率明显高于妊娠晚期感染率。妊娠次数小于两次及大于或等于两次的HPV感染率分别为15.41%、15.11%,无显著差异(P>0.05)。结论妊娠期妇女HPV感染以高危型及单基因型感染为主,常见亚型为HPV52、58、53、44型,年龄是影响妊娠妇女高危型HPV感染的因素。应加强妊娠期HPV的宣传与筛查工作。

Objective To analyze the typology and characteristics of human papilloma(HPV)virus infection in pregnant women in Xindu District and to guide the prevention and treatment of HPV infection during pregnancy.Methods We retrospectively analyzed the case data of pregnant women in the Xindu District People’s Hospital of Chengdu from January 2022 to August 2023.The HPV typing of all cases was detected by fluorescence PCR,and the results were statistically analyzed.Results Among the 1141 pregnant women,there were 174 cases of HPV infection,with an infection rate of 15.25%.The main types of high-risk infection were HPV52,58 and 53,while the low-risk types were HPV44 and 81.There were 123 cases of single genotype infection(10.78%),and the main infection types were HPV52,58 and 44.51 cases(4.47%)were infected with multiple genotypes,including 29 cases(2.54%)with double genotypes and 22 cases(1.93%)with triple or more genotypes.The infection rates of 16-25-year-old,26-35-year-old and 36-44-year-old were 5.35%,8.94%and 0.96%respectively,and the difference was statistically significant(P<0.05).The HPV infection rates in the early,second and third trimester of pregnancy were 7.36%,7.71%and 0.18%respectively,and the infection rate in the early and second trimester was significantly higher than that in the third trimester.The HPV infection rates of less than two pregnancies and more than or equal to two pregnancies were 15.41%and 15.11%respectively,and there was no significant difference(P>0.05).Conclusion HPV infection in pregnant women is dominated by high-risk and single-gene type infections,and the common subtypes are HPV52,58,53,and 44,and age is a factor affecting high-risk HPV infection in pregnant women.The publicity and screening of HPV in pregnancy should be strengthened.