重复横断面研究在疫苗保护效果评价中的应用

Application of the repeated cross-sectional study design for evaluation of vaccine effectiveness

疫苗上市后在真实世界中的保护效果(Vaccine effectiveness,VE)评价普遍采用观察性研究。重复横断面(Repeated cross-sectional,RCS)研究是一种特殊的观察性研究类型,能够在资源有限和相对较小成本的情况下获得更具推广性的研究结果。中国使用RCS研究调查评价VE较少。本文综述了RCS研究在VE评价中的应用原理、方法、优势和局限性,为中国开展基于RCS研究的VE评价提供理论依据和方法指导。

Post-marketing evaluation of vaccine effectiveness(VE)in the real world is generally conducted through observational studies.A repeated cross-sectional(RCS)study is a special type of observational study that can produce more generalizable result at a relatively low cost and in situations with limited resources.Few RSC studies have been used to evaluate VE in China.In this review,we describe principles,methods,strengths,and limitations of RCS studies for VE evaluation,aiming to provide a theoretical basis and methodological guidance for conducting VE evaluations based on RCS studies in China.