脊髓电刺激治疗顽固性疼痛相关机制的研究进展

Research progress on the mechanism of spinal cord stimulation in the treatment of intractable pain

顽固性疼痛是一个全球性医学难题,其病因复杂,疾病范围广,给患者的日常生活带来极大痛苦。近年来脊髓电刺激(SCS)在刺激靶点、刺激模式等方面不断改进,明显提高了治疗慢性疼痛的疗效。目前SCS的镇痛机制包括门控理论、大脑下行传导束抑制、局部血流灌注调节、神经胶质细胞功能重塑与疼痛感觉与情绪改善等,且不同刺激靶点及衍生的各种刺激模式所发挥的镇痛机制均有异同。本文对SCS治疗顽固性疼痛的相关机制研究进展进行了综述。

Intractable pain is a global medical problem and brings great pain to patients'daily life.The causes of intractable pain are complex and the range of diseases is wide.In recent years,the stimulation target,stimulation frequency and other aspects of spinal cord stimulation(SCS)have been improved,and the curative effect has been obviously improved.Current researches on SCS analgesic mechanism include gate-control theory,inhibition of cerebral descending control,regulation of local blood perfusion,remodeling of neuroglial cell function and improvement of sensational and emotional parts of pain.In addition,different stimulus targets and derived stimulus modes exert different mechanisms.This article reviews the research progress on the mechanism of spinal cord stimulation for intractable pain.