细胞移植技术在脊髓损伤修复中应用的研究进展

Application of cell transplantation technology in the repair of spinal cord injury:a review

脊髓损伤是一种严重的中枢神经系统疾病,致残致死率高,且发病率呈逐年上升趋势。传统治疗方式包括手术治疗、药物治疗及康复治疗,但疗效均不理想,患者的功能恢复十分有限。近年来,细胞移植技术通过将外源性细胞移植到受损部位,发挥促进神经元再生和神经通路重建的作用,已成为一种充满前景的脊髓损伤治疗策略。但目前细胞移植技术在脊髓损伤修复应用中仍存在移植细胞类型繁多、移植后细胞存活率低和移植时机剂量不确定等问题。为此,笔者就细胞移植技术在脊髓损伤修复中应用的研究进展进行综述,以期为临床治疗提供参考。

Spinal cord injury is a serious disease of the central nervous system characterized by high disability and mortality,and shows an increasing incidence over year.Traditional treatment methods include surgery,medication and rehabilitation therapy,but the therapeutic outcomes are generally unsatisfactory and the functional recovery of patients is very limited.In recent years,cell transplantation technology,with a role in promoting neuron regeneration and neural pathway reconstruction by transplanting exogenous cells to the injured site,has become a promising treatment strategy for spinal cord injury.However,at present,cell transplantation technology is still faced with problems such as the diversified transplanted cell types,poor survival rate of transplanted cells,and uncertainty in the timing and dosage of transplantation in the repair of spinal cord injury.To this end,the authors reviewed the research progress in the application of cell transplantation technology in the repair of spinal cord injury,aiming to provide a reference for the clinical treatment.