不同类型幽门螺杆菌合并反流性食管炎的临床病理特征分析

Clinical and pathological characteristics analysis of reflux esophagitis combined with different types of Helicobacter pylori

目的探讨分析不同类型幽门螺杆菌(Hp)感染合并反流性食管炎(RE)临床症状、疾病严重程度及血清胃功能指标的相关性。方法纳入2021年5月至2023年5月新疆维吾尔自治区人民医院确诊反流性食管炎患者580例为研究对象。按Hp抗体分型测定分为Ⅰ型Hp感染组、Ⅱ型Hp感染组和阴性组,分析各组间的临床资料和血清学指标。结果RE患者的Hp感染率为20.35%。Ⅰ型Hp感染组的典型和非典型临床症状均高于Ⅱ型Hp感染组(P均<0.05);Ⅰ型Hp感染组病理严重程度高于Ⅱ型Hp感染组和阴性组,差异有统计学意义(P均<0.05);Ⅰ型Hp感染组与Ⅱ型Hp感染组和阴性组比较,血清胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ、胃蛋白酶原比值比和胃泌素17水平均增高,差异有统计学意义(P均<0.05)。结论RE患者Hp感染率较低,不同类型Hp现症感染对RE疾病的发展存在差异。

Objective To explore the correlation analysis of clinical symptoms,disease severity and serum gastric function indicators of different types of Helicobacter pylori(Hp)infection combined with reflux esophagitis(RE).Methods A total of 580 patients diagnosed with reflux esophagitis in People's Hospital of Xinjiang Uygur Autonomous Region from May 2021 to May 2023 were enrolled as the study subjects.According to the Hp antibody typing test,they were divided into typeⅠHp infection group,typeⅡHp infection group and negative group,and the clinical data and serological indicators of each group were analyzed.Results The Hp infection rate in RE patients was 20.35%.The typical and atypical clinical symptoms of typeⅠHp infection group were higher than those of typeⅡHp infection group(P<0.05);the pathological severity of typeⅠHp infection group was higher than that of typeⅡHp infection group and negative group,and the difference was statistically significant(P<0.05);compared with typeⅡHp infection group and negative group,the serum levels of PGⅠ,PGⅡ,PGR and G-17 in typeⅠHp infection group were increased,and the difference was statistically significant(P<0.05).Conclusion The Hp infection rate in RE patients is low,and different types of Hp symptomatic infection have different effects on the development of RE disease.