Current opinions on large cellular models

1|INTRODUCTION.Large language models(LLMs)have made breakthroughs in natural language processing(NLP)and understanding,and have brought revolutions in many other fields[1-4].Inspired by those successes,several large cellular models(LCMs)adopting similar structures of LLMs have been developed for single-cell transcriptomics,including(but not limited to)scBERT[5],Geneformer[6],scGPT[7],scFoundation[8],and GeneCompass[9].The practices of these models have shown LCMs’power and potential in various biological tasks and illustrated the possibilities of revolutionizing future biological studies by LCMs.