香砂六君子汤化裁治疗功能性消化不良的Meta分析

Clinical efficacy of Xiangsha Liujunzi Decoction for functional dyspepsia:A Meta-analysis

目的运用Meta分析探讨香砂六君子汤化裁治疗功能性消化不良(functional dyspepsia,FD)的临床疗效。方法对知网数据库、中国生物医学文献数据库、维普数据库、万方数据库、PubMed、Embase和Cochrane Library这7类数据库进行计算机检索,以香砂六君子汤化裁治疗功能性消化不良相关的随机对照试验(randomized controlled trial,RCT)为检索对象,以2012年1月1日-2023年11月1日为检索时限,2名研究者独立对文献进行筛选、提取及评估,最后采用RevMan5.4软件进行Meta分析。结果共纳入12个RCT,共计1139例患者。Meta分析结果显示,治疗组的总有效率(P<0.00001)、治愈率(P<0.00001)、症状积分(P=0.001)、胃排空率(P<0.00001)均优于对照组,但复发率及不良反应的分析结果无统计学差异(P>0.05)。结论香砂六君子汤化裁治疗功能性消化不良疗效更佳,但因收录文献的质量及数量等限制,仍需进一步研究。

Objective The Meta analytical method is used to discuss the clinical efficacy of Xiangsha Liujunzi Decoction in the treatment of functional dyspepsia(FD).Methods Seven databases including CNKI,CBM,VIP Database,Wanfang Database,PubMed,Embase and Cochrane Library databases were retrieved by computer.The retrieval content was randomized controlled trial(RCT)that was related to the treatment of FD with Xiangsha Liujunzi Decoction.The retrieval period was from January 1,2012 to November 1,2023.According to inclusion and exclusion criteria,two researchers independently screened the literature,extracted information and evaluated quality.Finally,Meta analytical method was performed by using RevMan 5.4 software.Results 12 RCTs were involved in this study and the number of patients was 1139 in total.The results of Meta-analysis showed that the total effective rate(P<0.00001),cure rate(P<0.00001),symptom score(P=0.001)and gastric empting rate(P<0.00001)of the treatment group were better than those of the control group,but the analysis of recurrence rate and adverse reactions had no statistical significance.However,the analyses of recurrence rate and adverse reactions had no statistical significance(P>0.05).Conclusion Xiangsha Liujunzi Decoction is more effective in the treatment of FD.However,due to the influence of the quality and quantity of the included literature,follow-up large-sample and high-quality RCT studies are still needed to confirm this conclusion.