老年癫痫患者的丙戊酸钠联合拉莫三嗪治疗效果及对脑电图的影响

The therapeutic effect of valproic acid combined with lamotrigine on elderly epilepsy patients and its impact on electroencephalogram

目的探究丙戊酸钠联合拉莫三嗪治疗老年癫痫患者的临床效果及对脑电图的影响。方法选取2022年1月-2023年6月期间在我院神经内科就诊的80例老年癫痫患者,按数字表法随机分配。对照组40例,采用丙戊酸钠进行单一治疗;观察组40例,采用丙戊酸钠和拉莫三嗪联合治疗;并对其临床疗效、不良反应发生率和脑电图进行了比较。结果治疗后,观察组患者的临床总有效率显著高于对照组(P<0.05);观察组患者的不良反应总发生率显著低于对照组(P<0.05);两组治疗前的痫样放电与累计导联数比较,均未见显著性差异(P>0.05);观察组治疗后的痫样放电与累计导联数显著少于对照组(P<0.05);两组的癫痫发作次数和发作持续时间在治疗前均未见显著性差异(P>0.05);观察组治疗后的癫痫发作次数明显低于对照组(P<0.05),癫痫发作持续时间明显缩短(P<0.05)。结论丙戊酸钠与拉莫三嗪联合治疗老年癫痫,临床疗效明显,可有效降低不良反应发生率,减少癫痫发作次数,改善脑电图,是一种值得在临床上推广的治疗方法。

Objective To explore the clinical effect of valproic acid combined with lamotrigine in the treatment of elderly patients with epilepsy and its effect on EEG.Methods 80 elderly epileptic patients in the neurology department in our hospital between January 2022 and June 2023 were selected and randomly assigned according to the numerical method.In the control group,40 patients were treated as monotherapy with valproate and observation group 40 patients were combined with valproate and lamotrigine;the clinical efficacy,incidence of adverse effects and EEG were compared.Results After the treatment,the total clinical response rate of patients in the observation group was significantly higher than that in the control group(P<0.05);the overall incidence of adverse reactions in patients in the observation group was significantly lower than that in the control group(P<0.05);there was no significant difference between the pre-treatment epileptic discharge and involved lead number between the two groups(P>0.05);after the treatment,the number of epileptic discharges and the involved after in the observation group was significantly less than that in the control group(P<0.05);there was no significant difference in the number of seizures and the duration of seizures between the two groups before treatment(P>0.05);after the treatment,the number of seizures was significantly lower in the treatment group than in the control group(P<0.05),the duration of the seizure episode was significantly reduced(P<0.05).Conclusion The combination of valproic acid and lamotrigine in the treatment of senile epilepsy has obvious clinical effect,which can effectively reduce the incidence of adverse reactions,reduce seizures and improve electroencephalography,which is a treatment method worthy of popularizing in clinical practice.