替戈拉生与雷贝拉唑对胃食管反流患者食管动力学及血清胃肠激素的影响分析

Analysis of the Effects of Tegoprazan and Rabeprazole on Esophageal Dynamics and Serum Gastrointestinal Hormones in Patients with Gastroesophageal Reflux Disease

目的为分析替戈拉生与雷贝拉唑对胃食管反流(GER)患者食管动力学及血清胃肠激素的影响。方法本研究采用了前瞻性分析,选取2023年4月至2024年2月112例赣南医学院第三附属医院收治的GER患者,随机分为治疗组和对照组,每组各56例。治疗组给予替戈拉生联合雷贝拉唑治疗,对照组给予雷贝拉唑治疗。比较两组疗效,治疗前后临床症状评分、食管下段括约肌压力(LESP)、食管上段括约肌压力(UESP)、血清胃泌素(GAS)、胃动素(MTL)水平及不良反应。结果连续治疗8周,治疗组的疗效高于对照组(P<0.05)。治疗后,两组胃灼感、反酸、反食低于治疗前,LESP、UESP和GAS、MTL水平高于治疗前(P<0.05),且治疗组的胃灼感、反酸、反食低于对照组,LESP、UESP和GAS、MTL水平高于对照组(P<0.05)。两组不良反应差异无统计学意义(P>0.05)。结论替戈拉生与雷贝拉唑的联合使用对GER患者可提高临床疗效,改善食管动力学及血清胃肠激素水平,且安全性较好。

Objective To explore the effects of tegoprazan and rabeprazole on esophageal dynamics and serum gastrointestinal hormones in patients with gastroesophageal reflux(GER).Methods This study employed a prospective analysis,a total of 112 patients with GER admitted to The Third Affiliated Hospital of Gannan Medical College from April 2023 February 2024 were selected and randomly divided into treatment group and control group,with 56 patients in each group.The treatment group received tegoprazan plus rabeprazole and the control group received rabeprazole.Compared the efficacy of the two groups,clinical symptoms score,esophageal kinetic indicators[lower esophageal sphincter pressure(LESP),upper esophageal sphincter pressure(UESP)],serum gastrin(GAS),motilin(MTL)levels and adverse reactions.Results Continuous treatment for 8 weeks,the efficacy of the treatment group was higher than that of the control group(P<0.05).After treatment,heartburn sensation,acid reflux,and reverse eating were lower than before treatment,LESP,UESP,GAS,and MTL were higher than before treatment(P<0.05),and the heartburn sensation,acid reflux,and reverse eating were lower than the control group,and LESP,UESP,GAS,and MTL were higher than the control group(P<0.05).Adverse effects were not statistically different between the two groups(P>0.05).Conclusion The combination of tegoprazan plus rabeprazole can improve clinical efficacy,esophageal dynamics and serum gastrointestinal hormone levels in GER patients,and have good safety profile.