附子理中丸服药方法改变对减少脾肾阳虚的重症患者胃潴留的临床疗效观察

Observe the Clinical Effect of Changing the Taking Method of Fuzi Lizhong Pills on Reducing Gastric Retention in Severe Patients with Spleen and Kidney Yang Deficiency

目的观察附子理中丸服药方法改变对减少脾肾阳虚的重症患者胃潴留的临床疗效。方法选择2022年1月至2022年12月瑞金市中医院收治的鼻饲肠内营养支持的重症并发胃潴留(脾肾阳虚型)患者112例,随机分为对照组和观察组,每组56例。两组均给予附子理中丸治疗,观察组按照传统方法将附子理中丸煎煮后服用,对照组将附子理中丸溶化后直接服用,连续治疗30 d。比较两组胃残留量(GRV)、疗效、脾肾阳虚症状,以及不良反应发生情况。结果治疗第1天,两组患者GRV比较,差异无统计学意义(P>0.05);治疗后,观察组GRV小于对照组(P<0.05)。观察组总有效率为85.71%(48/56),高于对照组的75.00%(42/56),差异有统计学意义(P<0.05)。观察组脾肾阳虚相关症状评分小于对照组,差异有统计学意义(P<0.05)。结论与溶化后直接服用相比,传统煎煮附子理中丸的服药方法在减少脾肾阳虚的重症患者胃潴留方面表现出更好的疗效。

Objective To observe the clinical effect of changing the taking method of fuzi lizhong pills on reducing gastric retention in severe patients with spleen and kidney yang deficiency.Methods 112 severe patients with gastric retention(spleen and kidney yang deficiency type)admitted to Ruijin Hospital of Traditional Chinese Medicine from January 2022 to December 2022 were randomly divided into control group(n=56)and observation group(n=56).Both groups were treated with fuzi lizhong pills,the observation group took fuzi lizhong pills after decocting according to the traditional method,while the control group took fuzi lizhong pills directly after melting,all treated for 30 d.Gastric residual volume(GRV),curative effect,spleen and kidney yang deficiency symptoms and adverse reactions were compared between the two groups.Results There was no significant difference in GRV between the two groups on the first day of treatment,but the GRV of the observation group was lower than that of the control group after treatment.The total effective rate of the observation group(85.71%)was higher than that of the control group(75.00%)(P<0.05).The score of spleen and kidney yang deficiency in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The traditional decoction of fuzi lizhong pills show better effect in reducing stomach retention in severe patients with spleen kidney yang deficiency by directly taking it after dissolution.