架起中医药学与现代生物医学沟通的桥梁

Bridging up with Frontiers of the Modern Biomedical Research is of Essence for the Development of Traditional Chinese Medicine

如何推动发展中的中医药学与现代生物医学以及临床医学的深入沟通并实现互利共赢,成为中国现代医学实践和教育事业必须要认真面对的问题。现代生命科学的发生和发展经历了宏观、微观和实观3个世界。中医药学是基于宏观生物世界所建立的理论和实践体系,而现代生物医学科学在不到百年的时间里已经跨过微观世界而进入了实观世界。实观世界的科学范式是通活学,即将生命科学带进以时空为轴心的全参数、数字化、可数字孪生的新境界。尽管传统中医药学没有现代分子生物学的“分子-细胞”和“基因型-表型”等概念,但在过去的几十年里,现代中医药学,尤其是在中药研发方面,还是采纳了现代生物医学和药学的诸多科学方法和实验体系。如果运用中华传统哲学思想,指导性引进“五行”思维框架,将现代生命科学理论范畴分为“五流”(信息流、操作流、平衡流、分室流和可塑流),为中医药学理论和与现代医学理论沟通开拓了有效途径。

How to encourage deep communication and creating a win-win situation for the advancing traditional Chinese medicine and modern biomedicine as well as their clinical counterparts becomes a solemn problem for modern medicine practice and education in China.Modern life science has experienced three worlds or biospheres:macro-biosphere,micro-biosphere and holovivo-biosphere.The traditional Chinese medicine is based on theories and practices of macro-sphere but modern biomedical science has,in less than a millennium,passed micro-biosphere and entered holovivo-biosphere whose paradigm is holovivology,i.e.,adding a spatiotemporal axis for the life science through full-parameterization,digitalization,and digital-twin-based new landscape.Although there have not been certain key concepts of modern molecular biology in traditional Chinese medicine,such as molecule--cell and genotype-phenotype,modernized Chinese medicine in the past several decades,especially the research and development of traditional Chinese medicine,has accepted several scientific methods and experimental systems of the modern biomedicine.If Chinese philosophy can be applied to the changing biomedical frameworks,the introduction of 5-tracks(informational,operational,homeostatic,compartmental,and plastic tracks)biology,i.e.,holovivology,such a new conception may pave away for effective communication between traditional Chinese medicine and modern medicine.