酒精代谢活力的动态变化和性别二态性

Dynamic changes and sexual dimorphism of alcohol metabolic activity

目的:探究酒精多次摄入后代谢活力的动态变化,分析代谢酶代谢活力的诱导作用和性别差异。方法:采用呼气酒精检测仪器建立大鼠呼气末酒精检测方法并检测大鼠灌胃酒精后呼气酒精浓度,借此动态地测量大鼠摄入酒精后的血酒浓度经时变化,计算药代动力学参数,评价细胞色素P4502E1(cytochrome P4502E1,CYP2E1)代谢活力和大鼠性别差异。结果:随着酒精摄入次数的增加,CYP2E1代谢活力呈现诱导趋势(P<0.05);雌性大鼠酒精代谢活力强于雄性(P<0.05)。结论:酒精代谢和诱导作用具有性别二态性。

Objective:To explore the dynamic changes of metabolic activity after multiple intakes of alcohol,and to analyze the induction and gender differences of metabolic enzyme activity.Methods:The end-expiratory alcohol detection method of rats was established by breath alcohol detectors,and the breath alcohol concentration of rats after intragastric administration of alcohol was detected.The time-varying changes of blood alcohol concentration of rats after alcohol intake were dynamically measured,and the pharmacokinetic parameters were calculated to evaluate cytochrome P4502E1(CYP2E1)metabolic activity and gender differences in rats.Results:With the increase of alcohol intake,the metabolic activity of CYP2E1 showed an induced trend(P<0.05).The activity of alcohol metabolism in female rats was stronger than that in male rats(P<0.05).Conclusion:Alcohol metabolism and induction have sexual dimorphism.