基于“通因通用”理论温通经络竹刮疗法联合穴位贴敷治疗大肠湿热型溃疡性结肠炎的临床疗效

Clinical effect of Wentongjingluo bamboo scraping therapy combined with acupoint application in patients with ulcerative colitis of large intestine damp-heat:Based on the theory of"TongYinTongYong"

目的观察基于“通因通用”理论温通经络竹刮疗法联合穴位贴敷治疗大肠湿热型溃疡性结肠炎(UC)的临床疗效。方法将80例大肠湿热型UC患者按照随机数字表法分为2组,对照组40例予常规管理联合中药保留灌肠方案,观察组40例在对照组基础上予温通经络竹刮疗法联合穴位贴敷干预。2周后比较2组中医症状评分、Mayo评分及内镜评分、免疫功能指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、炎症因子[肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、IL-10、IL-1β]及生活质量的结果差异。结果2组干预后各项中医症状评分均降低(P<0.05),且观察组干预后均低于对照组(P<0.05)。2组干预后Mayo评分及内镜评分均降低(P<0.05),且观察组干预后均低于对照组(P<0.05)。2组干预后TNF-α、IL-6、IL-1β水平均降低(P<0.05),IL-10均升高(P<0.05),且观察组干预后TNF-α、IL-6、IL-1β水均低于对照组(P<0.05),IL-10高于对照组(P<0.05)。2组干预后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均升高(P<0.05),且观察组干预后均高于对照组(P<0.05)。2组干预后各项生活质量评分均升高(P<0.05),且观察组干预后均高于对照组(P<0.05)。结论温通经络竹刮疗法联合穴位贴敷能够改善大肠湿热型UC患者的临床症状,保护患者肠道黏膜,减轻炎症反应,调节免疫功能,提高患者生活质量。

Objective To observe the clinical effect of Wentongjingluo bamboo scraping therapy combined with acupoint application in patients with ulcerative colitis(UC)of large intestine damp-heat syndrome based on the theory of"TongYinTongYong".Methods A total of 80 patients with UC of large intestine damp-heat syndrome were included in this study.The subjects were divided into the experimental group(40 cases)and the control group(40 cases)by number table method.All patients were treated with conventional management combined with traditional Chinese medicine(TCM)retention enema,and those in the experimental group were additionally treated with Wentongjingluo bamboo scraping therapy combined with acupoint application intervention.Treated for two weeks,the aim was to compare TCM symptoms scores,Mayo score and endoscopic score,immune function indexes including CD3^(+),CD4^(+),CD4^(+)/CD8^(+),inflammatory factors including tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IL-10,IL-1β,and quality of life between groups.Results After treatment,the both groups had significantly reduced TCM symptom score,Mayo score and endoscopic score,decreased expressions of TNF-α,IL-6 and IL-1β,and increased expressions of IL-10,and CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)(all P<0.05),the experimental group was superior to the control group for the above indexes(all P<0.05).The quality of life scores of UC patients in the both groups were significantly higher than those before treatment,and the increases were more pronounced in the experimental group relative to the control group(P<0.05).Conclusion The combination of Wentongjingluo bamboo scraping therapy and acupoint application can improve the clinical symptoms,protect intestinal mucosa,reduce inflammation,mobilize immune function,and improve the quality of life of UC patients with large intestine damp-heat syndrome.