中药黄芪在皮肤病治疗中的应用

Application of Astragalus in the Treatment of Dermatosis

随着社会的不断进步和人们健康意识的不断提高,皮肤稳态日益受到重视,皮肤衰老、紫外线损伤、色素沉着等话题引发热议。目前临床上大多数皮肤病具有病程迁延、缠绵难愈的特点,往往伴随着瘙痒等不适感,患者治疗需求强烈。黄芪是目前临床上使用最广泛的中药之一,早在《神农本草经》中即被列为上品,享有“治疮痈之圣药”的美誉。现代临床研究以及临床前研究发现,黄芪可通过改善机体免疫状态、调节局部微循环、加强机体抗氧化能力等,促进皮肤创面愈合,减缓皮肤衰老进程,改善皮肤微循环,对抗紫外线损伤,缓解皮肤瘙痒,改善色素沉着,抵抗外界病毒,在皮肤病的治疗和预防中扮演重要角色。研究表明,皮肤病的发生与TNF-α、IL-1β和IL-6等炎性细胞因子的高表达相关,而现代药理学研究证明,黄芪中的有效成分如黄芪甲苷等,可通过调控PI3K/Akt等信号通路,对炎症反应起到一定的抑制作用,进而缓解相关临床症状,减轻患者不适感,提高患者生活质量。本研究综述黄芪在皮肤病治疗中的应用,以期对黄芪在防治皮肤病的临床应用提供指导和借鉴。

With the continuous progress of society and the improvement of people's health awareness,skin homeostasis is increasingly being emphasized,and skin aging,ultraviolet damage,and hyperpigmentation have become hot topics.At present,most clinical skin diseases are characterized by long duration and difficult to heal,often accompanied by itching and other intolerable discomfort,and patients have a strong demand for treatment.Astragalus is one of the most widely used traditional Chinese medicines in clinical practice,and was listed as the top grade in“Shennong's Classic of the Materia Medica”,enjoying the reputation of“the holy medicine for treating sores and carbuncles”.In modern clinical researches and preclinical researches,it is found that Astragalus can promote the healing of skin wounds,slow down the aging process of the skin,improve the microcirculation of the skin,fight against ultraviolet damage,relieve skin itching,improve pigmentation,resist external viruses by improving the immune state of the body,regulating the local microcircula-tion,and strengthening the antioxidant capacity of the body,which plays an important role in the treatment and prevention of skin dis-eases.Modern studies have shown that the occurrence of skin diseases is associated with the high expression of inflammatory cytokines such as TNF-α,IL-1βand IL-6,and modern pharmacological studies have proved that the effective components in Astragalus,such as astragaloside,can play a certain inhibitory effect on inflammatory reactions by regulating the signaling pathways such as PI3K/Akt,thus alleviating the relevant clinical symptoms,reducing the discomfort of patients and improving the quality of life of patients.This paper describes the application of Astragalus in the treatment of skin diseases,which is of great significance in guiding the clinical application of Astragalus in the prevention and treatment of dermatologic diseases.