养阴清肺颗粒联合HRZE化疗方案治疗初治敏感肺结核的效果

Effect of Yangyin Qingfei Granules Combined with HRZE Chemotherapy in the Treatment of Initial Sensitive Pulmonary Tuberculosis

目的探讨养阴清肺颗粒联合异烟肼+利福平+吡嗪酰胺+乙胺丁醇(HRZE)化疗方案治疗初治敏感肺结核的临床效果。方法回顾性收集2022年6月至2023年3月河南省胸科医院收治的95例初治敏感肺结核患者的临床资料,根据治疗方案分为对照组(47例,HRZE化疗方案治疗)和观察组(48例,HRZE化疗方案+养阴清肺颗粒治疗),均持续治疗6个月。比较两组疗效、肺功能指标(用力肺活量、呼气峰流速、第1秒用力呼气容积)、免疫功能指标,以及治疗期间不良反应发生情况。结果观察组总有效率高于对照组(P<0.05)。治疗6个月时,观察组肺功能指标、免疫功能指标均高于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论初治敏感肺结核患者采用HRZE化疗方案联合养阴清肺颗粒治疗效果显著,可改善患者免疫功能和肺功能,且不会增加不良反应。

Objective To explore the clinical effect of Yangyin Qingfei Granules combined with isoniazid+rifampicin+pyrazinamide+ethambutol(HRZE)chemotherapy in the treatment of newly diagnosed sensitive pulmonary tuberculosis.Methods Clinical data of 95 newly treated sensitive pulmonary tuberculosis patients admitted to Henan Provincial Chest Hospital from June 2022 to March 2023 were retrospectively collected.They were divided into a control group(47 cases,treated with HRZE chemotherapy regimen)and an observation group(48 cases,treated with HRZE chemotherapy regimen and Yangyin Qingfei Granules)according to different treatment plans,all of which were continuously treated for 6 months.The efficacy,lung function indexes(forced vital capacity,peak expiratory flow,forced expiratory volume in the first second),immune function indexes and side effects during treatment were compared in both groups.Results The total effective rate of observation group was higher than that of control group(P<0.05).At 6 months of treatment,the lung function and immune function indicators in the observation group were higher than those in the control group(P<0.05).There was no statistical significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of HRZE chemotherapy regimen and Yangyin Qingfei Granules has a significant therapeutic effect on newly treated sensitive pulmonary tuberculosis patients,which can improve their immune and lung functions without increasing the incidence of side effects.