小儿肺咳颗粒与硫酸特布他林联合治疗儿童急性支气管肺炎的疗效

Therapeutic Effect of the Combination of Xiao'er Feike Granules and Terbutaline Sulfate in the Treatment of Acute Bronchopneumonia in Children and Its Impact on Symptom Improvement Time

目的探讨小儿肺咳颗粒与硫酸特布他林联合应用于急性支气管肺炎患儿的效果。方法选择2020年6月—2023年9月兰陵县人民医院收治的86例急性支气管肺炎患儿为研究对象,采用随机数表法将其分成对照组和观察组,各43例。对照组采用硫酸特布他林雾化吸入用溶液吸入治疗,观察组在对照组基础上采用小儿肺咳颗粒治疗。对比两组的临床疗效、症状改善时间、炎症因子、不良反应发生情况。结果观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组体温恢复正常时间、肺部哮鸣音消失时间、咳嗽咳痰消失时间均短于对照组,组间差异有统计学意义(P<0.05)。治疗前,两组超敏C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平比较,组间差异无统计学意义(P>0.05);治疗后,观察组CRP、IL-8、TNF-α水平均低于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论小儿肺咳颗粒联合硫酸特布他林治疗急性支气管肺炎患儿,可增强疗效,能够显著缩短临床症状的恢复时间,缓解患儿的炎症反应,且安全性良好。

Objective To explore the effect of the combination of Xiao'er Feike Granules and Terbutaline Sulfate on children with acute bronchopneumonia.Methods A total of 86 children with acute bronchopneumonia admitted to Lanling County People's Hospital from June 2020 to September 2023 were selected as the research objects and randomly divided into a control group and an observation group using a random number table method,with 43 cases in each group.The control group received nebulized inhalation solution of terbutaline sulfate,while the observation group received an additional dose of Xiao'er Feike Granules on the basis of the control gorup.Compare the clinical efficacy,symptom improvement time,inflammatory factors,and adverse reactions between the two Groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The time for the observation group's body temperature to return to normal,the time for the disappearance of pulmonary wheezing,and the time for the disappearance of cough and sputum were all shorter than those of the control group,and the differences between the groups were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α)between the two groups(P>0.05);After treatment,the levels of CRP,IL-8,and TNF-αin the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Xiao'er Feike Granules and Terbutaline Sulfate in the treatment of acute bronchopneumonia in children can enhance the therapeutic effect,significantly shorten the recovery time of clinical symptoms,relieve inflammatory reactions in pediatric patients,and have good safety.