通淋促排汤联合坦索罗辛治疗经皮肾镜碎石取石术后残留结石的效果

Effect of Tonglin Cupai Decoction Combined with Tamsulosin in the Treatment of Residual Stones after Percutaneous Nephrolithotripsy

目的探讨通淋促排汤联合坦索罗辛治疗经皮肾镜碎石取石术(PCNL)术后残留结石的效果。方法选取2021年10月—2023年10月我院收治的80例PCNL术后残留结石患者为研究对象,采用随机数字表法将其分为对照组和联合组,各40例。对照组给予坦索罗辛治疗,联合组给予通淋促排汤联合坦索罗辛治疗。对比两组的临床疗效、中医证候积分、炎症因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]水平、不良反应发生情况。结果联合组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组中医证候积分比较,组间差异无统计学意义(P>0.05);治疗后,联合组腹痛/少腹急满、小便频数短赤、涩痛难忍/淋漓不爽、恶寒发热中医证候积分均低于对照组,组间差异有统计学意义(P<0.05)。治疗前,两组IL-6、CRP、TNF-α水平比较,组间差异无统计学意义(P>0.05);治疗后,联合组IL-6、CRP、TNF-α水平均低于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论通淋促排汤联合坦索罗辛能改善PCNL术后残留结石患者的症状,减轻炎症反应,有利于结石排出,治疗安全有效。

Objective To explore the effect of Tonglin Cupai Decoction combined with Tamsulosin in the treatment of residual stones after percutaneous nephrolithotripsy(PCNL).Methods A total of 80 patients with residual stones after PCNL surgery admitted to our hospital from October 2021 to October 2023 were selected as the research subjects.They were randomly divided into a control group and a combination group using a random number table method,with 40 cases in each group.The control group was treated with tamsulosin,while the combined group was treated with Tonglin Cupai Decoction combined with tamsulosin.Compare the therapeutic effects,traditional Chinese medicine syndrome scores,inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)]and adverse reactions between the two groups.Results The total effective rate of the combination group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the scores of traditional Chinese medicine syndromes between the two groups(P>0.05);after treatment,the combination group had lower scores of traditional Chinese medicine symptoms such as abdominal pain/low abdominal distension,short and red urine frequency,unbearable astringency/dripping discomfort,and aversion to cold and fever compared to the control group,and the differences between the groups were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in IL-6,CRP,and TNF-αlevels between the two groups(P>0.05);after treatment,the levels of IL-6,CRP,and TNF-αin the combination group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Cupai Decoction Tang and Tamsulosin can improve the symptoms of patients with residual stones after PCNL surgery,reduce inflammatory reactions,promote stone excretion,and treat safely and effectively.