瑞巴派特片联合枸橼酸莫沙必利片对慢性萎缩性胃炎患者血清炎症因子、胃肠功能指标的影响

Effects of Rebamipide Tablets Combined with Mosapride Citrate Tablets on Serum Inflammatory Factors and Gastrointestinal Function Indicators in Patients with Chronic Atrophic Gastritis

目的探究瑞巴派特片联合枸橼酸莫沙必利片在慢性萎缩性胃炎中的应用效果。方法选取2020年5月—2023年5月寿光市人民医院收治的86例慢性萎缩性胃炎患者为研究对象,按随机数字表法将其分为对照组和观察组,每组43例。对照组采用枸橼酸莫沙必利片治疗,观察组在此基础上采用瑞巴派特片治疗。比较两组患者的临床疗效、血清炎症因子、胃肠功能指标及不良反应发生情况。结果观察组的治疗总有效率为93.02%,高于对照组的76.74%,差异有统计学意义(P<0.05)。治疗后,观察组的C反应蛋白、肿瘤坏死因子-α、降钙素原及白细胞介素-6水平均低于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组的胃动素及胃泌素水平均高于对照组,生长抑素水平低于对照组,组间差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论瑞巴派特片联合枸橼酸莫沙必利片治疗慢性萎缩性胃炎的效果理想,可降低患者的血清炎症因子水平,改善其胃肠功能指标,加快病情康复,安全可靠。

Objective To study the effects of rebamipide tablets combined with mosapride citrate tablets in chronic atrophic gastritis.Methods A total of 86 patients with chronic atrophic gastritis treated in Shouguang People's Hospital from May 2020 to May 2023 were selected as the research objects and were divided into a control group and an observation group according to random number table method,with 43 cases in each group.The control group was treated with mosapride citrate tablets,and the observation group was treated with rebamipide tablets on this basis.The clinical efficacy,serum inflammatory factors,gastrointestinal function indexes and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.02%,which was higher than 76.74%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of C-reactive protein,tumor necrosis factor-α,procalcitonin and interleukin-6 in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of motilin and gastrin in the observation group were higher than those in the control group,and the level of somatostatin was lower than that in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Rebamipide tablets combined with mosapride citrate tablets are effective in the treatment of chronic atrophic gastritis,which can reduce the levels of serum inflammatory factors,improve gastrointestinal function indexes,accelerate the recovery of the disease,and is safe and reliable.