胎盘冻干粉治疗腰背肌筋膜炎患者失眠焦虑症状的疗效观察

Observation on the curative effect of placenta lyophilized powder in the treatment of insomnia and anxiety symptoms in patients with low back myofascitis

目的分析胎盘冻干粉治疗腰背肌筋膜炎患者失眠焦虑症状的疗效。方法选取122例腰背肌筋膜炎伴失眠焦虑症状患者作为研究对象,根据随机数字表法分为治疗组和对照组,每组61例。两组患者均口服双氯芬酸钠缓释片治疗,在此基础上,对照组口服安慰剂,治疗组口服胎盘冻干粉。比较两组患者干预前后匹兹堡睡眠质量指数量表(PSQI)评分、视觉模拟评分法(VAS)评分、焦虑自评量表(SAS)评分及血清5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)水平。结果干预后,两组PSQI、VAS、SAS评分均低于本组干预前,且治疗组PSQI评分(7.87±1.81)分、VAS评分(3.72±1.04)分、SAS评分(50.52±7.78)分均低于对照组的(9.67±2.48)、(5.36±1.22)、(62.49±4.56)分,差异具有统计学意义(P<0.05)。干预后,两组5-HT低于本组干预前、BDNF高于本组干预前,且治疗组5-HT(39.39±5.67)ng/ml低于对照组的(48.07±2.59)ng/ml、BDNF(12.17±2.36)ng/ml高于对照组的(9.75±2.03)ng/ml,差异具有统计学意义(P<0.05)。结论腰背肌筋膜炎伴失眠焦虑症状患者口服胎盘冻干粉,可以明显改善患者的疼痛、焦虑及睡眠质量。

Objective To analyze the curative effect of placenta lyophilized powder in the treatment of insomnia and anxiety symptoms in patients with low back myofascitis.Methods 122 patients with low back myofascitis accompanied by insomnia and anxiety symptoms were selected as the research subjects.The patients were divided into a treatment group and a control group using random numerical table,with 61 cases in each group.Both groups of patients were treated with oral diclofenac sodium sustained-release tablets.On this basis,the control group received oral placebo,while the treatment group received oral placental lyophilized powder.Both groups were compared in terms of Pittsburgh Sleep Quality Index(PSQI)score,Visual Analogue Scale(VAS)score,Self-rating Anxiety Scale(SAS)score,serum 5-hydroxytryptamine(5-HT)and brain-derived neurotrophic factor(BDNF)before and after intervention.Results After intervention,the scores of PSQI,VAS and SAS in both groups were lower than those before intervention;the treatment group had PSQI score of(7.87±1.81)points,VAS score of(3.72±1.04)points and SAS score of(50.52±7.78)points,which were lower than(9.67±2.48),(5.36±1.22)and(62.49±4.56)points in the control group;the difference was statistically significant(P<0.05).After intervention,5-HT in both groups was lower than that before intervention,BDNF was higher than that before intervention;the treatment group had lower 5-HT of(39.39±5.67)ng/ml than(48.07±2.59)ng/ml in the control group,and higher BDNF of(12.17±2.36)ng/ml than(9.75±2.03)ng/ml in the control group;the difference was statistically significant(P<0.05).Conclusion Oral administration of placenta lyophilized powder can significantly improve the pain,anxiety and sleep quality of patients with low back myofascitis accompanied by insomnia and anxiety symptoms.