烯丙雌醇联合阿托西班治疗先兆早产对患者症状缓解时间、保胎成功率的影响

Effect of Allestradiol Combined with Atosiban on Symptom Remission Time and Success Rate of Fetal Preservation in Patients with Threatened Premature Delivery

目的探究烯丙雌醇联合阿托西班治疗先兆早产对患者症状缓解时间、保胎成功率的影响。方法选择淄博市临淄区妇幼保健院2022年2月—2023年2月收治的90例先兆早产患者为研究对象,按随机数字表法将其分为对照组及观察组,每组45例。两组均接受一般治疗,在此基础上,对照组采用烯丙雌醇片治疗,观察组采用烯丙雌醇联合阿托西班治疗。对比两组患者的临床症状缓解时间、保胎情况、保胎成功率、围产儿结局及不良反应发生情况。结果观察组的保胎成功率为97.78%,高于对照组的82.22%,差异有统计学意义(P<0.05)。观察组的宫缩消失时间、腹痛消失时间及止血时间均短于对照组,孕龄延长时间长于对照组,组间差异有统计学意义(P<0.05)。观察组的新生儿Apgar评分高于对照组,差异有统计学意义(P<0.05)。观察组的围产儿不良结局发生率低于对照组,差异有统计学意义(P<0.05)。观察组的不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论烯丙雌醇联合阿托西班能够加快先兆早产患者临床症状缓解,提高保胎成功率,改善围产儿结局,临床疗效显著且安全性较高,值得临床推广使用。

Objective To investigate the effect of allestradiol combined with atosiban on the symptom remission time and the success rate of fetal preservation in patients with threatened premature delivery.Methods Ninety patients with threatened premature delivery admitted to Zibo City Linzi District Maternal and Child Health Hospital from February 2022 to February 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 45 cases in each group.Both groups received general treatment,on this basis,the control group was treated with allestradiol tablets,and the observation group was treated with allestradiol combined with atosiban.The duration of clinical symptom relief,fetal preservation,success rate of fetal protection,perinatal outcome and adverse reactions were compared between the two groups.Results The success rate of the observation group was 97.78%,which was higher than 82.22%of the control group,the difference was statistically significant(P<0.05).The time of contraction disappearance,abdominal pain disappearance and hemostasis in the observation group were shorter than those in the control group,and the prolongation time of gestational age was longer than that in the control group,the differences between the groups were statistically significant(P<0.05).The neonates Apgar score in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The incidence of perinatal adverse outcomes in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Allestradiol combined with atosiban can accelerate the relief of clinical symptoms in patients with threatened premature delivery,improve the success rate of fetal protection,and improve the perinatal outcome.The clinical efficacy is significant and the safety is high,and it is worthy of clinical promotion.