瑞巴派特联合常规四联疗法对Hp感染慢性萎缩性胃炎患者胃肠激素及胃蛋白酶原的影响

Effect of Rebamipide Combined with Routine Quadruple Therapy on Gastrointestinal Hormones and Pepsinogen in Patients with Chronic Atrophic Gastritis Infected by Hp

目的探讨瑞巴派特联合常规四联疗法在幽门螺旋杆菌(Hp)感染慢性萎缩性胃炎(CAG)患者中的疗效。方法选择该院2021年5月—2023年6月收治的70例Hp感染CAG患者为研究对象,按随机数字表法将其分为对照组和观察组。对照组(n=35)采用常规四联疗法治疗,观察组(n=35)在对照组基础上联合瑞巴派特治疗,两组均持续治疗2周。对比两组胃肠激素、胃蛋白酶原水平、不良反应发生情况及Hp根除率。结果治疗后,观察组胃泌素水平低于对照组,胃动素、生长抑素水平均高于对照组,组间差异有统计学意义(P<0.05);观察组胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ水平均高于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率相比,差异无统计学意义(P>0.05)。观察组Hp根除率97.14%高于对照组的77.14%,差异有统计学意义(P<0.05)。结论瑞巴派特联合常规四联疗法在Hp感染CAG患者中具有较好的应用效果,利于改善胃肠激素与胃蛋白酶原水平,还可提升Hp根除率与治疗安全性。

Objective To explore the therapeutic effect of ribavirin combined with conventional quadruple therapy in patients with chronic atrophic gastritis(CAG)caused by Helicobacter Pylori(Hp)infection.Methods A total of 70 patients with CAG caused by Hp infection admitted to the hospital from May 2021 to June 2023 were selected as the research objects,and they were divided into a control group and an observation group according to the random number table method.The control group(n=35)received conventional quadruple therapy,while the observation group(n=35)received a combination of remifentanil and remifentanil on the basis of the control group.Both groups received continuous treatment for 2 weeks.Compare the levels of gastrointestinal hormones,pepsinogen,occurrence of adverse reactions,and Hp eradication rates between two groups.Results After treatment,the level of gastrin in the observation group were lower than those in the control group,while the level of motilin and somatostatin were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05);the levels of pepsinogen I and pepsinogen II in the observation group were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The Hp eradication rate in the observation group was 97.14%higher than 77.14%in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of remifentanil and conventional quadruple therapy has a good application effect in patients with CAG caused by Hp infection,which is beneficial for improving gastrointestinal hormone and pepsinogen levels,as well as enhancing Hp eradication rate and treatment safety.