依达拉奉右莰醇注射用浓溶液和丁苯酞氯化钠注射液联合治疗急性脑梗死的有效性及安全性探讨

Efficacy and Safety of Edaravone and Dextrocamphorol Concentrated Solution for Injection Combined with Butylphthalein and Sodium Chloride Injection in the Treatment of Acute Cerebral Infarction

目的探究依达拉奉右莰醇注射用浓溶液和丁苯酞氯化钠注射液在急性脑梗死患者中的治疗效果。方法选取2021年1月—2023年10月山东省荣军总医院收治的68例急性脑梗死患者为研究对象,按随机数字表法将其分为对照组与观察组,各34例。对照组采用丁苯酞氯化钠治疗,观察组在对照组基础上加用依达拉奉右莰醇治疗,比较两组临床疗效、神经功能、血液流变学、血管内皮功能及不良反应发生情况。结果观察组治疗总有效率为94.12%,高于对照组的76.47%,差异有统计学意义(P<0.05)。治疗后,观察组美国国立卫生院卒中量表评分、全血高切黏度、全血低切黏度、血浆黏度及内皮素-1水平均低于对照组,一氧化氮水平高于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论依达拉奉右莰醇和丁苯酞联用治疗急性脑梗死效果较佳,可改善患者神经功能及血液流变学指标,减轻血管内皮损伤,安全性较高。

Objective To investigate the therapeutic effect of edaravone and dextrocampbodol concentrated solution for injection and butylphthalide and sodium chloride injection on acute cerebral infarction.Methods A total of 68 patients with acute cerebral infarction admitted to Shandong Rongjun General Hospital from January 2021 to October 2023 were selected as the research objects.According to the random number table method,they were divided into a control group and an observation group,with 34 cases in each group.The control group was treated with butylphthalide and sodium chloride,and the observation group was treated with edaravone dexborneol on the basis of the control group.The clinical efficacy,nerve function,hemorheology,vascular endothelial function and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.12%,which was higher than 76.47%of the control group,the difference was statistically significant(P<0.05).After treatment,the National Institutes of Health Stroke Scale score,high blood viscosity,low blood viscosity,plasma viscosity and endothelin-1 level in the observation group were lower than those in the control group,and the level of nitric oxide was higher than that in the control group,the differences between the two groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Edaravone and dextrocamphorol combined with butylphthalide is effective in the treatment of acute cerebral infarction,which can improve the neurological function and hemorheology index,reduce vascular endothelial injury,and has high safety.